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Diss Factsheets
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EC number: 225-863-2 | CAS number: 5124-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The main conclusions in this chapter have been prepared in accordance with the draft SIDS initial assessment report OECD (2005).
The inherent property of 4,4’-methylenedicyclohexyl diisocyanate is to hydrolyse in an aquatic environment. The hydrolysis product is - beside insoluble oligomeric and polymeric ureas - the corresponding 4,4´-methylenedicyclohexyl diamine. As the half life of the parent substance was determined to be 2 h and as the test solutions were stirred for 24 h it can be assumed that only the hydrolysis products were present in the test solutions andand thus potential effects were caused by the hydrolysis products rather than bythe parent substance. In the following the toxicity of 4,4’-methylenedicyclohexyl diisocyanate and its hydrolysis products is reported. Tests were conducted according to the GLP requirements and specially laid down test conditions.
Before the actual start of each ecotoxicity study (Danio rerio (formerly Brachydanio rerio), Daphnia magna and Scenedesmus subspicatus) pre-treatments were performed with 4,4’-methylenedicyclohexyl diisocyanate according to the recommendation mentioned in the “OECD Guidance Document on aquatic toxicity testing of difficult substances and mixtures” in order to accelerate test substance solution. For that purpose the solutions of the test substance were prepared at a nominal concentration that was 5-fold higher than the maximum water solubility reported for 4,4’‑methylenedicyclohexyl diisocyanate in preliminary tests. The solutions were treated in water with ultra-turrax 60 s/8000 rpm, afterwards stirred for 24 hours on a magnetic stirrer and finally filtered. Because of the short half-life of 4,4’-methylenedicyclohexyl diisocyanate, testing with the degradation products is required and has been conducted as seen in this test. Filtration removed additional insoluble hydrolysis products. Substance concentrations (mainly the soluble hydrolysis product methylene bis(4-cyclohexyldiamine)) were determined as TOC and back-calculated to the parent compound.
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