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EC number: 204-596-5 | CAS number: 123-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD 403 under GLP conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- BIBRA toxicology international
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-ethylhexanal
- EC Number:
- 204-596-5
- EC Name:
- 2-ethylhexanal
- Cas Number:
- 123-05-7
- Molecular formula:
- C8H16O
- IUPAC Name:
- 2-ethylhexanal
- Details on test material:
- - Analytical purity: 2-ethylhexanal 97.96% determined with GC
- Impurities (identity and concentrations): 2-ethylhexenal 0.11 %, 2-ethylhexanol 0.05 %, water 0.34 %
Identity of 2-ethylhexanal confirmed using 1H-NMR spectrum
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Olac Ltd., Bicester, Oxon, UK
- Weight at study initiation: approximately 150 g
- Fasting period before study: no fasting
- Housing: polypropylene cages with stainless-steel mesh tops and floors suspended over paper for the removal of excreta
- Diet: ad libitum except chamber acclimatisation and exposure
- Water: ad libitum except chamber acclimatisation and exposure
- Acclimation period: 4 h daily exposure to air alone, on 3 d prior to study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 45-70
- Air changes (per hr): at least 15
- Photoperiod (hrs dark / hrs light): 12/12 (06.00 - 18.00 GMT/18.00 - 06.00 GMT)
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION (Limit2)
- Exposure apparatus: all-glass inhalation chamber
- Exposure chamber volume: 70 l
- Method of holding animals in test chamber: stainless-steel wire mesh cage
- Source and rate of air: 40 l/min
- System of generating aerosols: steady infusion of the material into a concentric jet atomiser through which 40 l/min of air was passed. Atmosphere was passed into a mixing vessel in heating mantle (100 °C) containing glass fibre filter pads.
TEST ATMOSPHERE
- Brief description of analytical method used: gas-liquid chromatography
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Concentration within the exposure chamber was measured using gas-liquid chromatography
- Duration of exposure:
- 4 h
- Concentrations:
- Two Limit tests (Limit 1+2) were performed (nominal concentrations):
-Limit 1: 6.4 +/- 0.43 mg/L (1199 +/- 80.5 ppm)
-Limit 2: 10.68 mg/L (2000 ppm)
Analytical concentrations:
-Limit1: 1.62 +/- 1.20 mg/L (303 +/- 224.7 ppm)
-Limit2: 6.83 +/- 1.32 mg/L (1279 +/- 247 ppm)
LIMIT2: maximum concentration exceeds 5 mg/L (936 ppm) requiered under OECD 403 - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations each day, frequent observation of variation of conditions and behaviour; weighing on days -3, 0, 1, 2, 7, 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 6.83 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality observed within 4 h - vapor was tested
- Mortality:
- No mortality observed
- Clinical signs:
- other: During exposure: gradual reduction in respiratory rate combined with reduction to noise stimuli (most severe at 2 h of exposure) Irritations of the mucosa, nostrils and eyes (closed) had reddish-brown colouration, reversible within 3 d
- Body weight:
- Weight reduction for 2 d after exposure followed by a weight increase. Overall body weight development was positive.
- Gross pathology:
- Pale pink to deep-red colouration of the lungs (all animals), pale kidneys (2x males), opaque eyes with a small milky area (1x male)
Applicant's summary and conclusion
- Executive summary:
Study is conducted under GLP conditions and according to OECD guideline 403 (valid without restrictions). 5 Rats/sex were exposed for 4 h to 6.83 mg/L (vapour). No mortality occurred. Observed clinical effects and necropsy findings point to irritating properties of the substance.
Conclusion:
Acute inhalative toxicity LD50 > 6.83 mg/L/4h.
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