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EC number: 231-403-1 | CAS number: 7534-94-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the log Pow value of 5.09 only a bioaccumulation potential of Isobornyl methacrylate can be assumed. But due to an expected rapid metabolism of Isobornyl methacrylate in the environment based on in vivo studies in rats and a non bioaccumulating potential of the metabolites Isoborneol and Methacrylic acid, Isobornyl methacrylate is not expected to bioaccumulate in organisms.
Additional information
The octanol/water partition coefficient of the of Isobornyl methacrylate was measured according HPLC method with log Kow of 5.09. Log Kow > 4.5 predicts a potential for bioaccumulation. On the contrary, an experimental study (Fraunhofer, 2006) has been carried out on the structural related 2-ethyl hexyl methacrylate (log Kow > 4.5) to assess the fish bioconcentration of the substance, according to OECD guideline 305. This study demonstrates that rapid metabolisation occurs, preventing any significant accumulation (BCF = 37). Moreover, for (meth)acrylate esters in general, it was demonstrated that the first metabolic step is hydrolysis to (meth)acrylic acid and the according alcohol catalysed by unspecific carboxyl esterases which are widespread in organs and tissues of metabolic relevance for organisms potentially affected by bioaccumulation.
This approach is supported by non GLP in vivo metabolism studies in rats via intravenous administration with Isobornyl acrylate (IBOA, CAS 5888-33-5), Isobornyl acetate (IBOAc, CAS 125 -12 -2) and Isobornyl methacrylate (IBOMA, CAS 7534 -94 -3) (see chapter 7.1 Toxicokinetics, metabolism and distribution): Rapid hydrolysis was observed in an initial distribution step with average calculated t1/2 values of 2-3 minutes for IBOA, IBOAc and IBOMA. The primary hydrolysis products Isoborneol and the different acids are not expected to bioaccumulate based on their log Kow (source: KOWWIN v1.68): Isoborneol (CAS 124 -76 -5, log Kow 2.85), Acrylic acid (CAS 79-10-7, log Kow: 0.44), Acetic acid (CAS 64-19-7, log Kow 0.09), Methacrylic acid (CAS 79-41-4, log Kow: 0.99) . Similar metabolism is expected in fish as carboxylesterases are ubiquitous enzymes.
Table: LogKow of the primary metabolites of Ethylhexyl methacrylate and Isobornyl methacrylate.
Substance
|
CAS |
LogKow [KOWWIN v1.68] |
Ethylhexyl alcohol |
104-76-7 |
2.73 |
Methacrylic acid |
79-41-4 |
0.99 |
Isoborneol |
124-76-5 |
2.85 |
Acrylic acid |
79-10-7 |
0.44 |
Metabolites with log Kow < 4.5 are not predicted to bioaccumulate in organisms.
Due to the common phase I metabolism with carboxylesterases and common substance groups of the first metabolites which are alkyl alcohols and (meth) acrylates the analog approach for the endpoint bioaccumulation is justified and the assessment of bioaccumulation based on the log Kow of the metabolites is plausible.
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