Registration Dossier
Registration Dossier
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EC number: 221-410-8 | CAS number: 3087-36-3
Toxicity to aquatic plants other than algae
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as this substance is hydrolytically unstable and the decomposition products have a low potential for aquatic bioaccumulation and a low potential to cross biological membranes. Toxicity (7-d NOEC and EC50) of the main decomposition product ethanol is used as a key value.
Key value for chemical safety assessment
- EC50 for freshwater plants:
- 4 432 mg/L
- EC10 or NOEC for freshwater plants:
- 280 mg/L
Additional information
When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than ethanol and hydrated titanium dioxide (key study on hydrolysis Brekelmans M.J.C. 2013). The organic decomposition product ethanol is readily biodegradable having also a low log Kow value (-0.3). The CSA indicates that toxicity of this substance is similar to the main degradation product ethanol. Key studies (short-term toxicity to daphnia and algae, Klimisch score 1) conducted for the analogue category member (titanium tetraisopropanolate, CAS 546-68-9) justify that these organometallic titanates hydrolyse during toxicity testing and the aquatic toxicity is similar to the alcohol released in water. Category and read-across justifications are presented in the annexes of the CSR.
Because of rapid hydrolysis (half-life few minutes), a toxicity study on plants is unjustified, and the key value for CSA is obtained from the most reliable 7-d EC50 and NOEC- values of ethanol (peer-reviewed secondary source, Cowgill et al. 1991). In this well reported study that was carried out to guideline, five species of duckweed (Lemna gibba) and 4 clones of Lemna minor, 6591, 7010, 7102 and 7136) were exposed to ethanol over a concentration range of 1 to 21000mg/l over a 7 day period. The measures of growth inhibition used to assess toxicity were number of plants, number of fronds and total dry biomass at the end of the study compared to controls. The measures of number of plants in particular but also the number of fronds to a lesser extent proved highly variable with some species, as shown by the very large confidence intervals. The lowest results were obtained with Lemna gibba, which also showed lower variability in the values, and is therefore used as the key value in CSA.
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