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EC number: 210-036-0 | CAS number: 603-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- October 1950 and September 1951
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 952
- Report date:
- 1952
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: BASF-internal standard method. The acute toxicity to rats after a single subcutaneous administration of a 20% oily suspension, equivalent to doses of 1000, 3000, 4000, 5000 and 6000 mg/kg test material, was evaluated. After application, the animals were observed 8 days for mortality and syptoms of acute intoxication. Dead animals, time to death and symptoms of acute intoxication were recorded. The mean lethal dose was determined.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Triphenylphosphine
- EC Number:
- 210-036-0
- EC Name:
- Triphenylphosphine
- Cas Number:
- 603-35-0
- Molecular formula:
- C18H15P
- IUPAC Name:
- triphenylphosphine
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final dilution of a suspended solid: 20 %
FORM AS APPLIED IN THE TEST (if different from that of starting material): oily suspension
Test animals
- Species:
- mouse
- Strain:
- other: albino
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- other: 20% TS in olive oil
- Doses:
- 1000, 3000, 4000, 5000, 6000 mg/kg bw
- No. of animals per sex per dose:
- 1000 mg/kg bw: 5 animals
3000 mg/kg bw: 8 animals
4000 mg/kg bw: 8 animals
5000 mg/kg bw: 8 animals
6000 mg/kg bw: 3 animals - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days.
- Frequency of observations: at least daily.
- Necropsy of survivors performed: no.
- Other examinations performed: clinical signs.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 000 mg/kg bw
- Remarks on result:
- other: Mortality occured.
- Mortality:
- Mortality of 5/8, 7/8, 7/8, 3/3 animals was observed in dose groups of 3000, 4000, 5000 and 6000 mg/kg bw, respectively. Death occured within 1-3 days after application. At 1000 mg/kg bw no animal died.
- Clinical signs:
- Animals that died showed tonic-clonic seizures, accelerated breathing and impaired balance. No clinical findings in all surviving animals.
Any other information on results incl. tables
Table 1. Mortality
Dose |
Number |
Dead |
Time to |
6000 |
3 |
3/3 |
1 |
5000 |
8 |
7/8 |
1-2 |
4000 |
8 |
7/8 |
1-3 |
2000 |
8 |
5/8 |
1 |
1000 |
5 |
0/5 |
- |
Applicant's summary and conclusion
- Executive summary:
Single doses of 1000 to 6000 mg/kg bw were administered subcutanoeously to 3 (high dose), 5 (low dose) or 8 (mid dose groups) mice per group as 20-% suspension in olive oil. Mortality of 5/8, 7/8, 7/8, 3/3 animals was observed in dose groups of 3000, 4000, 5000 and 6000 mg/kg bw, respectively. Death occurred within 1-3 days after application. At 1000 mg/kg bw no animal died during an observation period of 8 days. Animals that died showed tonic-clonic seizures, accelerated breathing and impaired balance, whereas surviving animals appeared normal. An LD50 of 3000 mg/kg was determined.
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