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EC number: 231-439-8 | CAS number: 7550-35-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-08-14 to 1997-01-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- October 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Version / remarks:
- December 29th 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-3 (Acute inhalation toxicity)
- Version / remarks:
- November 1984
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Lithium bromide
- EC Number:
- 231-439-8
- EC Name:
- Lithium bromide
- Cas Number:
- 7550-35-8
- Molecular formula:
- BrLi
- IUPAC Name:
- lithium bromide
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Kingston, NY
- Age at study initiation: 7-9 weeks (young adults)
- Weight at study initiation: 218-332 g
- Housing: individually housed in stainless steel suspended rat cages
- Diet (e.g. ad libitum): Purina Laboratory Rodent Chow 5001, ad libitum
- Water (e.g. ad libitum): fresh tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 67-71
- Humidity (%): 35-72
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: The 11 L ADG nose-only exposure chamber was made of anodized aluminium and was operated dynamically.
- Method of holding animals in test chamber: Animals were housed in polycarbonate nose-only tubes.
- Source and rate of air: breathing grade compressed air; Chamber airflow of 28.1 L/min
- System of generating particulates/aerosols: TSI 6-jet atomizer
- Method of particle size determination: The aerodynamic particle size distribution was determined by gravimetric analysis of the amount of test material collected on the impactor stages. The mass median aerodynamic diameter (MMAD), geometric standard deviation and the percent of aerosol less than or equal to 1,10, and 15 microns in size were determined by logarithmic-probability plotting.
- Treatment of exhaust air: The chamber air was exhausted from the bottom of the chamber and passed through an orifice tube system which continuously monitored airflow and then through a commercial filter box.
- Temperature, humidity, pressure in air chamber: Chamber and room air temperature and relative humidity were monitored continuously during the exposure with wet/dry bulb hygrometers. Measurements were recorded at 30 minute intervals.
TEST ATMOSPHERE
- Brief description of analytical method used: Chamber air samples were taken on desiccated GelmanType A/E 37 mm glass fiber filters held in cassettes. Samples were taken hourly during the exposure to determine the airborne concentration of test material.
- Samples taken from breathing zone: Yes, the samples were taken from the center of the chamber directly above the animal tube portals.
TEST ATMOSPHERE
- Particle size distribution: Chamber air samples were also taken twice during the exposure to determine the aerodynamic particle size distribution of airborne test material. The samples were drawn through a Sierra® Model 218 cascade impactor at 2.80 liters per minute.
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): The mass median aerodynamic diameter (MMAD), geometric standard deviation and the percent of aerosol less than or equal to 1,10, and 15 microns in size were determined by logarithmic-probability plotting. - Duration of exposure:
- 4 h
- Concentrations:
- mean wet concentration: 15.57 mg/L
nominal exposure concentration: 16 mg/L - No. of animals per sex per dose:
- five animals sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed for signs of toxicity and mortality at fifteen minute intervals during the first hour of exposure, hourly for the remainder of the exposure, upon removal from the chamber, at one hour post-exposure and daily thereafter for fourteen days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Particle size distributions were determined by log-probability plotting of the data and subsequent determination of the mass median aerodynamic diameter, geometric standard deviation and other particle size parameters from the data plots. The LC50 and 95% confidence limits were determined by a suitable logit or probit analysis.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 15.57 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: Treatment-related clinical signs noted during the study included alopecia, chromodacryorrhea, chromorhinorrhea, decreased feces, decreased locomotion and oral discharge. Other signs attributed to excessive soiling as a result of animal tube confinement in
- Body weight:
- One female lost weight during the 7-14 day interval. At termination, all animals exhibited increases in body weight over their day 0 values.
- Gross pathology:
- There were no gross internal lesions observed in any animal at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this acute inhalation toxicity study, the four-hour LC50 for lithium bromide solution was greater than 15.57 mg/L.
- Executive summary:
The acute inhalation toxicity study according to OECD guideline 403 and EU methode B.2 was performed with lithium bromide. A group of five male and five female Sprague-Dawley rats was exposed to lithium bromide solution for 4 hours at a concentration of 15.57 mg/L in a dynamically-operated, nose-only inhalation exposure chamber. Gravimetric airborne test material samples were taken hourly during the exposure. Particle size samples were taken twice during the exposure. Observations for toxicity and mortality were performed frequently during the exposure, upon removal of the rats from the chamber, at one hour post-exposure and daily thereafter for 14 days. Individual body weights were recorded immediately prior to exposure on day 0 and on days 7 and 14. On day 14, all animals were sacrificed and gross necropsy examinations were performed. All animals survived to study termination. Treatment-related clinical signs observed during the study included alopecia, chromodacryorrhea, chromorhinorrhea, decreased feces, decreased locomotion and oral discharge. All animals were in normal condition from day 2 of study through day 14 with the exception of one rat with alopecia from day 11 through 13 of the study. All animals gained weight during the study. No gross internal lesions were noted during necropsy. Under the conditions of this study, the four-hour LC50 for lithium bromide solution was greater than 15.57 mg/L.
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