Registration Dossier
Registration Dossier
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EC number: 220-250-6 | CAS number: 2687-91-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non-GLP study and non-guideline study, but basic information given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- similar to OECD 401
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-ethylpyrrolidin-2-one
- EC Number:
- 220-250-6
- EC Name:
- 1-ethylpyrrolidin-2-one
- Cas Number:
- 2687-91-4
- Molecular formula:
- C6H11NO
- IUPAC Name:
- 1-ethylpyrrolidin-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): N-ethylpyrrolidon
- Molecular weight : 113
- Physical state: liquid
- Analytical purity: > 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The mean body weights for males was 208 g and for females 165 g.
The animals were offered Herilan MRH concentrated feed and water ad libitum. Feed was withdrawn 16 hours before the beginning of the study.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 10.0; 21.5; 31.6 and 50% solution in distilled water in doses of 1,000; 2,150; 3,160 and 5,000 mglkg
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 200 mg/kg bw
- Mortality:
- see below
- Clinical signs:
- other: see below
- Gross pathology:
- Animals that died: Heart: acute dilatation; kidneys: some of them pale; lungs: infarctoid congestion with edematization; intestines: atonic
Sacrificed animals: Organs: no abnormalities detected
Any other information on results incl. tables
Mortality:
| Dose (mg/kg) | Conc. (%) | No. of animals | Died within | ||||
| 1 hour | 24 hours | 48 hours | 7 days | 14 days | |||
| 5,000 | 50 | 5 males | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 |
| 5 females | 0/5 | 3/5 | 4/5 | 4/5 | 4/5 | ||
| 3,160 | 31.6 | 5 males | 0/5 | 0/5 | 1/5 | 1/5 | 1/5 |
| 5 females | 0/5 | 2/5 | 4/5 | 4/5 | 4/5 | ||
| 2,150 | 21.5 | 5 males | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
| 5 females | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | ||
| 1,000 | 10.0 | 5 males | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
| 5 females | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | ||
Symptoms:
| 5,000 mg/kg | 3,160 mg/kg | 2,150 mg/kg | 1,000 mg/kg | |
| Dyspnea | 15 min - 6 d | < 15 min - 4 h | 1 h - 5 h | |
| Apathy | 15 min - 5 d | < 15 min - 4 h | 1 h - 5 h | |
| Lateral position | 1 h - 2 d | 30 min - 4 h | ||
| Abdominal position | 30 min - 4 h | 2 h - 4 h | ||
| Dorsal position | 4 h | |||
| Staggering | 15 min - 1 d | < 15 min - 4 h | ||
| Atony | 1 h - 4 h | |||
| Paresis | 15 min - 2 d | |||
| Pain reflex absesnt | 1 h | |||
| Narcotic-like state | 1 h | |||
| Urine orange | 1 d - 5 d | |||
| Erythema | 1 h - 2 d | |||
| Exsiccosis | 1 h - 2 d | |||
| Ames blood test | 15 min - 6 d | < 15 min - 4 h | 1 h - 5 h |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
