Registration Dossier
Registration Dossier
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EC number: 221-499-3 | CAS number: 3121-61-7
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (28d) > 1000 mg/kg dw (nominal) (soil microorganisms, OECD 217), RA
Key value for chemical safety assessment
Additional information
Since no data on the toxicity of 2-methoxyethyl acrylate (CAS 3121-61-7) to soil microorganisms are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 read-across to another structurally related analogue substance was conducted. Read-across data from methyl acrylate (CAS 96 -33 -3) were used, which was considered suitable for read-across.
The key study was conducted according to GLP and OECD guideline 217 using soil microorganisms as test organisms. Within this study on carbon transformation, nominal test concentrations of 0, 63, 125, 250, 500, and 1000 mg/kg dry mass soil were applied, and glucose-induced respiration rates were measured. No analytical measurements of the test concentrations were conducted. As a result, a 28d-EC50 value of > 1000 mg/kg dw was determined based on nominal concentrations (BASF SE, 2010).
Due to structural and property similarities with the tested analogue substance, it can be concluded that the above result also applies to 2-methoxyethyl acrylate (CAS 3121-61-7). For details see analogue justification in the overall summary of Chap 6.1 and in Chapter 13 of the Technical Dossier.
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