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Diss Factsheets
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EC number: 203-813-0 | CAS number: 110-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis - application to cases from rubber gloves
- Author:
- Kaniwa M, Isama K, Nakamura A, Kantoh H, Hosono K, Itoh M, Shibata K, Usuda T, Asahi K, Osada T, Matsunaga K, Uleda H
- Year:
- 1 994
- Bibliographic source:
- Contact Dermatitis, 31, 65 -71
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Five cases of allergic contact dermatitis from rubber gloves were investigated using a combination of patch testing in patients and chemical analysis of causative rubber products by gas chromatography (GC) and high-performance liquid chromatography (HPLC).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Piperidine
- EC Number:
- 203-813-0
- EC Name:
- Piperidine
- Cas Number:
- 110-89-4
- Molecular formula:
- C5H11N
- IUPAC Name:
- piperidine
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): piperidine
no further data
Method
- Type of population:
- other: patients with allergic contact dermatitis
- Subjects:
- - Number of subjects exposed: 4
- Sex: 3 males, one female
- Age: 31, 38, 49, and 51 years
- Race: no data - Clinical history:
- ophthalmologist, used surgical gloves: itchy eruption, thereafter, edema, infiltrative erythema and serious eruption appeared on fingers and hands;
gilder: developed contact dermatitis on the hands and arms, sensitive to a brand of rubber work gloves, and to surgical rubber gloves not used before;
nurse: contact dermatitis on the hands, arms and face, sensitive to brands of surgical rubber gloves;
surgeon: contact dermatitis on the hands and forearms, sensitive to surgical rubber gloves. - Controls:
- No data
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- Piperidine was confirmed analytical as an ingredient of the rubber material (rubber accelerators) of rubber gloves.
In the patch test performed with piperidine two of the four patients were hypersensitive to piperidine.
Result of the patch test:
- One case showed a positive reaction on day 2 and 3;
- One case on day 3.
- One case showed no positive reaction to the test item.
- No data about the sensitivity to the test item was obtained for one case.
The authors noticed that in addition to other ingredients in rubber gloves, piperidine, which occurs in the quantities up to several 0.3 to 2.5 mg per g should be considered as a cause of allergic contact dermatitis.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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