Registration Dossier
Registration Dossier
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EC number: 600-736-8 | CAS number: 106276-80-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- no data on purity; occlusive testing in 6 animals for 24 h; missing 48 h reading; no information on environmental conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Fed. Reg. 38 No. 187 § 1500.42
- Deviations:
- no
- Principles of method if other than guideline:
- - Limitations: no data on purity; occlusive testing in 6 animals for 24 hrs; missing 48 h reading, no information on environmental conditions
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
- EC Number:
- 226-999-5
- EC Name:
- 3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
- Cas Number:
- 5590-18-1
- Molecular formula:
- C22H6Cl8N4O2
- IUPAC Name:
- 3,3'-(1,4-phenylenediimino)bis(4,5,6,7-tetrachloro-1H-isoindol-1-one)
- Reference substance name:
- mono/bis-methoxy derivatives
- Molecular formula:
- C22-24H6-12Cl6-8N4O2-4
- IUPAC Name:
- mono/bis-methoxy derivatives
- Test material form:
- solid: bulk
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Analytical purity: no data
Test animals
- Species:
- rabbit
- Strain:
- other: Russian
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1.5 - 2 kg
- Housing: separately
- Diet (e.g. ad libitum): NAFAG, Gossau SG, rabbit food; ad lib.
- Water (e.g. ad libitum): unspecified; ad lib.
ENVIRONMENTAL CONDITIONS
not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: polyethylene glycol trituration (PEG 400)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): 50% - Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6 (3 males and 3 females)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5*2.5 cm on back or flanks
- Type of wrap if used: gauze patch covered with plastic film
REMOVAL OF TEST SUBSTANCE
not reported
SCORING SYSTEM: OECD Draize Scoring System
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 & 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 & 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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