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EC number: 279-632-6 | CAS number: 80939-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 23, 1981 - December 7, 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with restrictions: - observation period of 14 days, but reversibility of the effects was not completed - no detailed information of the test substance
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (observation period of 14 days, but reversibility of the effects was not completed, no detailed information of the test substance)
- GLP compliance:
- no
Test material
- Reference substance name:
- Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates
- EC Number:
- 279-632-6
- EC Name:
- Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates
- Cas Number:
- 80939-62-4
- Molecular formula:
- Unspecified
- IUPAC Name:
- Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, CH-4414 Fuellinsdorf
- Weight at study initiation: 2 to 3 kg
- Housing: individually in metal cages
- Diet (ad libitum): standard rabbit food - NAFAG, No. 814
- Water (ad libitum): drinking water
- Acclimation period: min. of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the right eye was not treated and served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml - Duration of treatment / exposure:
- single treatment of all animals; in 3 of the 9 rabbits approximately 30 seconds after treatment the treated eye was flushed with 10 ml of physiological saline.
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 6 males and 3 females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): In 3 of the 9 rabbits approximately 30 seconds after treatment the treated eye was flushed with 10 ml of physiological saline.
SCORING SYSTEM: as described in OECD Guideline 405
TOOL USED TO ASSESS SCORE: hand-slit lamp
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 - 48 -72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 -48 -72 h
- Score:
- 2.28
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 14 days (in 2 of 5 animals)
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 2.11
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days (in 3 of 5 animals)
- Other effects:
- Besides a transient anorexia of one animal on day 11, no symptoms were observed.
One female animal died on day 8 independently of the compound administration.
Besides spotted lungs no gross lesion were found.
Any other information on results incl. tables
Table 1: Rabbit eye irritation scores after single treatment with the test substance (m=males, f=females), here the results of the treated eyes, that were not rinsed, are given:
Observation time |
Animal |
Cornea |
Iris |
Conjuctiva |
|||
|
|
OP |
AR |
|
RED |
SW |
DI |
24 H |
1 (m) |
0 |
0 |
0 |
2 |
1 |
0 |
|
2 (m) |
1 |
4 |
0 |
3 |
3 |
1 |
|
3 (m) |
1 |
1 |
0 |
2 |
2 |
2 |
|
4 (f) |
1 |
3 |
0 |
2 |
2 |
1 |
|
5 (f) |
0 |
0 |
0 |
2 |
2 |
1 |
|
6 (f) |
1 |
2 |
0 |
2 |
3 |
2 |
48 H |
1 (m) |
0 |
0 |
0 |
2 |
1 |
0 |
|
2 (m) |
1 |
3 |
0 |
3 |
2 |
1 |
|
3 (m) |
0 |
0 |
0 |
2 |
1 |
1 |
|
4 (f) |
1 |
1 |
0 |
2 |
2 |
1 |
|
5 (f) |
0 |
0 |
0 |
2 |
2 |
1 |
|
6 (f) |
2 |
2 |
0 |
3 |
3 |
2 |
72 H |
1 (m) |
0 |
0 |
0 |
2 |
2 |
0 |
|
2 (m) |
1 |
1 |
0 |
2 |
2 |
1 |
|
3 (m) |
0 |
0 |
0 |
2 |
2 |
0 |
|
4 (f) |
1 |
1 |
0 |
3 |
3 |
2 |
|
5 (f) |
0 |
0 |
0 |
2 |
2 |
0 |
|
6 (f) |
2 |
2 |
0 |
3 |
3 |
2 |
7 days |
1 (m) |
0 |
0 |
0 |
1 |
2 |
0 |
|
2 (m) |
0 |
0 |
0 |
2 |
2 |
0 |
|
3 (m) |
0 |
0 |
0 |
1 |
1 |
0 |
|
4 (f) |
0 |
0 |
0 |
2 |
2 |
0 |
|
5 (f) |
0 |
0 |
0 |
1 |
2 |
1 |
|
6 (f) |
1 |
1 |
0 |
2 |
2 |
1 |
14 days |
1 (m) |
0 |
0 |
0 |
1 |
1 |
4 |
|
2 (m) |
0 |
0 |
0 |
0 |
1 |
2 |
|
3 (m) |
0 |
0 |
0 |
0 |
0 |
0 |
|
4 (f) |
- |
- |
- |
- |
- |
- |
|
5 (f) |
0 |
0 |
0 |
0 |
0 |
0 |
|
6 (f) |
0 |
0 |
0 |
1 |
1 |
4 |
Mean (24-48-72 h) |
1 (m) |
0.00 |
0.00 |
0.00 |
2.00 |
1.33 |
0.00 |
|
2 (m) |
1.00 |
2.67 |
0.00 |
2.67 |
2.33 |
1.00 |
|
3 (m) |
0.33 |
0.33 |
0.00 |
2.00 |
1.67 |
1.00 |
|
4 (f) |
1.00 |
1.67 |
0.00 |
2.33 |
2.33 |
1.33 |
|
5 (f) |
0.00 |
0.00 |
0.00 |
2.00 |
2.00 |
0.67 |
|
6 (f) |
1.67 |
2.00 |
0.00 |
2.67 |
3.00 |
2.00 |
Mean |
|
0.67 |
1.11 |
0.00 |
2.28 |
2.11 |
1.00 |
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this experiment the test material was found to cause irritation when applied to the rabbit eye mucosa.
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