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Diss Factsheets
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EC number: 939-518-5 | CAS number: 68439-49-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 - 18 Nov 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted in 1981
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hexadecan-1-ol
- EC Number:
- 253-149-0
- EC Name:
- Hexadecan-1-ol
- Cas Number:
- 36653-82-4
- Molecular formula:
- C16H34O
- IUPAC Name:
- hexadecan-1-ol
- Reference substance name:
- 2-(hexadecyloxy)ethanol
- EC Number:
- 218-373-5
- EC Name:
- 2-(hexadecyloxy)ethanol
- Cas Number:
- 2136-71-2
- Molecular formula:
- C18H38O2
- IUPAC Name:
- 2-(hexadecyloxy)ethanol
- Reference substance name:
- 2-[2-(Hexadecyloxy)ethoxy]ethanol
- EC Number:
- 610-892-9
- Cas Number:
- 5274-61-3
- Molecular formula:
- C20H42O3
- IUPAC Name:
- 2-[2-(Hexadecyloxy)ethoxy]ethanol
- Reference substance name:
- 2-[2-[2-(Hexadecyloxy)ethoxy]ethoxy]ethanol
- Cas Number:
- 4484-59-7
- Molecular formula:
- C22H46O
- IUPAC Name:
- 2-[2-[2-(Hexadecyloxy)ethoxy]ethoxy]ethanol
- Reference substance name:
- 2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethanol
- Cas Number:
- 5274-63-5
- Molecular formula:
- C24H50O5
- IUPAC Name:
- 2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethanol
- Reference substance name:
- Octadecan-1-ol
- EC Number:
- 204-017-6
- EC Name:
- Octadecan-1-ol
- Cas Number:
- 112-92-5
- Molecular formula:
- CH3(CH2)17OH
- IUPAC Name:
- octadecan-1-ol
- Reference substance name:
- 2-(octadecyloxy)ethanol
- EC Number:
- 218-374-0
- EC Name:
- 2-(octadecyloxy)ethanol
- Cas Number:
- 2136-72-3
- Molecular formula:
- C20H42O2
- IUPAC Name:
- 2-(octadecyloxy)ethanol
- Reference substance name:
- 2-[2-(Octadecyloxy)ethoxy]ethanol
- EC Number:
- 605-213-8
- Cas Number:
- 16057-43-5
- Molecular formula:
- C22H46O3
- IUPAC Name:
- 2-[2-(Octadecyloxy)ethoxy]ethanol
- Reference substance name:
- 2-[2-[2-(Octadecyloxy)ethoxy]ethoxy]ethanol
- EC Number:
- 610-180-8
- Cas Number:
- 4439-32-1
- Molecular formula:
- C24H50O
- IUPAC Name:
- 2-[2-[2-(Octadecyloxy)ethoxy]ethoxy]ethanol
- Reference substance name:
- 2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethanol
- Cas Number:
- 59970-10-4
- Molecular formula:
- C26H54O5
- IUPAC Name:
- 2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethanol
- Reference substance name:
- 2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
- Cas Number:
- 71093-13-5
- Molecular formula:
- C28H58O6
- IUPAC Name:
- 2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
Constituent 9
Constituent 10
Constituent 11
Test animals
- Species:
- rat
- Strain:
- other: Bor:WISW (SPF TNO)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Weight at study initiation: 107 g
- Housing: 1 - 5 animals in Macrolon cages (type III)
- Diet: R10 Alleindiät für Ratten, Ssniff Spezialfutter GmbH, Soest, Germany, ad libitum
- Water: Tap water, ad libitum
- Fasting period before study: 16 h
- Acclimation period: 4 - 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1
- Humidity (%): 60 ± 5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 14 Nov 1986 To: 18 Nov 1986
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 11.905 mL/kg bw
DOSAGE PREPARATION: The test substance was heated to 50 °C and applied undiluted by oral gavage. - Doses:
- 10000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing: prior to dosing and on Days 1, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross necropsy
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: The only clinical sign of toxicity was piloerection. 2 h after dosing all animals were free of clinical signs.
- Gross pathology:
- No effects were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
- Conclusions:
- For the test substance a LD50 (rat, m/f) > 10000 mg/kg bw was determined in a study according to OECD guideline 401.
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