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EC number: 208-046-5 | CAS number: 506-59-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- Report-Date 1980-05-06
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Method: other: BASF-Test, experimental result
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethylamine
- EC Number:
- 204-697-4
- EC Name:
- Dimethylamine
- Cas Number:
- 124-40-3
- IUPAC Name:
- N-methylmethanamine
- Details on test material:
-
- Name of test material (as cited in study report): Dimethylamin, 40%-ige waessrige Loesung
- Name of test material (as cited in study report): Dimethylamin, 40%-ige waessrige Loesung
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Weight at study initiation: male 192 g (mean); female 160 g (mean)
- Diet: Herilan MRH-Haltung, Heinrich Eggersmann KG, Rinteln
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: dissolved in water with 0.5 % CMC
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 6.81 - 46.4 %
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg
- Doses:
- 681, 1000, 1470, 2150, 3160 and 4640 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 000 mg/kg bw
- Mortality:
- No animal died in the lowest dose group. Four out of 10 died in the 1000 mg/kg group. All animals died in the four highest dose groups.
- Clinical signs:
- other: staggering, atony, spatic gait, exsiccosis, tremor, salivation, opisthotonus, poor general state, reduction in body weight, "morphinschwanz"
- Gross pathology:
- Animals that died:
Heart: acute dilatation and congestive hyperemia
Lung: slight emphysema
Gastro-intestinal tract: redness, bloody content
Liver: peripheral lobule marking
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dimethylamine 40 % aqueous solution was harmful after oral gavage to Spraque-Dawley rats (according to C&L Regulations No. 1272/2008). An LD50 was deduced: 1000 mg/kg bw.
- Executive summary:
BASF conducted in 1980 an oral acute toxicity testing in Sprague-Dawley rats with dimethylamine 40 % aqueous solution. The substance was administered to the rats via oral gavage (Concentration in vehicle: 6.81 - 46.4 %, max. dose applied: 10 ml/kg). The different doses were 681, 1000, 1470, 2150, 3160 and 4640 mg/kg. After the observation period of 14 days (clinical signs were recorded), all animals were necropsied and additionally histopathological examinations were performed. In the lowest dose group (each group consisting of 10 animals) no animal died. In contrast in the group dosed with 1000 mg/kg bw, 4 of 10 animals died, and all animals in the higher dosed groups died. The clinical signs of the treated animals were staggering, atony, spatic gait, exsiccosis, tremor, salivation, opisthotonus, poor general state, reduction in body weight and a "morphinschwanz". Necropsy and histopathological examinations revealed in the animals that died an acute dilatation and congestive hyperemia of the heart, slight emphysema of the lung, redness and bloody content in the gastro-intestinal tract and peripheral lobule marking in the liver. In conclusion a LD50 of 1000 mg/kg bw was deduced.
In the present study, DMA aqueous was used. The substance is known to be corrosive and toxic if swallowed or inhaled. The substance Dimethylamine hydrochloride (CAS-No. 506-59-2, EC-No. 208-046-5) is a near analogue to Dimethylamine (CAS-No. 124-40-3, EC-No. 204-697-4). Merely from comparing the molecular structures of those two substances it is apparent that Dimethylamine hydrochloride (Dimethylammonium hydrochloride; DMA-HCl) and Dimethylamine (DMA) are closely related to each other. DMA-HCl is the chloride of DMA or morespecifically, the gas DMA reacts with hydrochloric acid to form the salt DMA-HCl, an odourless white solid. At this DMA`s unshared electron pair on nitrogen forms a coordinate bond with the proton hydrogen, accompanied by chlorine bonding ionically. If alkali (e.g. sodium hydroxide) is added to solutions of DMA-HCl the free amine DMA will be liberated. Hence, under specific conditions the toxicological and ecotoxicological properties of the gaseous substance DMA and its salt DMA-HCl (even in aqueous solution) are equal and as a result, read across is justified. Similar to the native DMA, DMA HCl will exert its toxicity in the same range of severity because of its dissociation to free amine in weak alkali body fluids.
Classification is warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
DMA HCl has been classified according to DSD as: Xn, R22 Harmful, Harmful if swallowed;
DMA HCL has been classified according to GSH: Acute Tox. 4, H302: Harmful if swallowed.
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