Registration Dossier
Registration Dossier
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EC number: 217-421-2 | CAS number: 1843-05-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- shorter observation period, reporting details
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Octabenzone
- EC Number:
- 217-421-2
- EC Name:
- Octabenzone
- Cas Number:
- 1843-05-6
- Molecular formula:
- C21H26O3
- IUPAC Name:
- [2-hydroxy-4-(octyloxy)phenyl](phenyl)methanone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CF Nelson
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- applied as 20% suspension in water
- Doses:
- 10000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: mortality daily, weighing at the beginning and the end
- Necropsy of survivors performed: yes
- Other examinations performed: none - Statistics:
- not required
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: no clinical signs observed
- Gross pathology:
- no findings upon necropsy
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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