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EC number: 415-510-2 | CAS number: 145703-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Acute aquatic toxicity of test substance was assessed in a 96-hour limit test on fish and in a 48 -hour limit test on daphnia.
Since no mortality of fish was seen, a LC50 > 86 mg/l as measured concentration (100 mg/l as nominal concentration) was found.
Exposure of daphnia to a filtrate solution did not induce acute immobilisation at measured concentrations ranging from 47 to 24 mg/l after 48 h. Hence an EC50 > 36 mg/l on average was found.
On the other hand, exposure to a supersaturated solution of 100 mg/l induced significantly immobilisation. This corresponded to concentrations of 81 and 45 mg/l in the 48 h exposure period. However, this effect on mobility was not indicative of a substance toxicity but more likely of mechanical obstruction of the ability to swim, caused by the presence of substance deposits.
Toxicity to aquatic algae was studied in a 72 -hour test. Analytically determined test substance concentrations in freshly prepared test media varied in the range from 47 % to 94.5 % of nominal values. At the end of the test, concentrations were in a range from 35.4 % to 49.7 % of nominal values due to a sedimentation of the suspended test substance.
As demonstrated by a modified test specifically developed for dyes, effects on algal biomass and growth rate were only due to the indirect action of test substance, namely light absorption. Any toxic effect of test substance on algal cells could be excluded up to the highest tested concentration of 41.2 mg/l (measured concentration corresponding to nominal concentration of 100 mg/l).
The toxicity to microorganisms was also studied. Since no inhibition of respiration rate was seen at all tested concentrations, an EC50 > 100 mg/l was determined.
According to the CLP Regulation (EC 1272/2008), the threshold of classification of a substance for short-term aquatic toxicity is 1 mg/l. Consequently, the substance is not classified for acute aquatic toxicity based on results obtained with fish, crustacea and aquatic algae.
In order to assess the potential toxicity upon chronic exposure, the substance was tested for long-term toxicity to crustacea (daphnia), which resulted as the most sensitive organism in the short-term studies.
Accordingly, a 22 -day test on daphnia was carried out. The analytically determined test substance concentrations in the samples from freshly prepared media varied in the range from 37 % to 101.7 % of nominal values. At the end of the renewal periods of 48 and 72 hours, measured concentrations were in the range from 31.9 % to 60.3 % of nominal values. The reason for these low measured levels was a sedimentation of the suspended test substance.
Based on the survival rate and the reproduction rate of the daphnia, a NOEC of 1.8 mg/l was determined.
No-observed effect concentrations for daphnia and algae, NOEC of 1.8 and 41.2 mg/l respectively, are above the threshold of classification for chronic toxicity (1 mg/l) of the CLP Regulation (EC 1272/2008). In addition, chronic toxicity to fish can be reasonably excluded based on the negative result with daphnia, namely the most sensitive species in acute toxicity studies,
.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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