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Diss Factsheets
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EC number: 906-125-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- Acute toxicity:
Oral: LD50: 3600 mg/kg for rat (geraniol)
Oral: LD50: 4500 mg/kg for rat (nerol)
Dermal: LD50: >5000 mg/kg for rabbit (geraniol and nerol)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 600 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Oral
Geraniol
The acute oral toxicity of geraniol was analyzed in a study with five Osborne-Mendel rats per sex and dose (Jenner, 1964). After Fasting for 18 h, the animals were administered by gavage and observed for 14 days. Since mortality was observed between 4 hours and 18 h after dosing, a LD50 of 3600 mg/kg bw was estimated. Although the used material showed additional isomer composition, this study was regarded as reliable since it was cited by several publications, including in the WHO Food Series published by the WHO.
In another study, geraniol in propylene glycol was administered up to eight rats of mixed strains per dose group at concentrations of 1, 5, 10, 100, 1000, 2000, 5000 mg/kg bw (Yamawaki, 1962). Since three of five rats of the high dose group died within the 48 h observation period, the LD50 was calculated to be 4800 mg/kg bw.
In a short report, which could not be taken into account for assessment, LD50 values of 2100-4500 mg/kg and 3500 mg/kg bw were reported as for rats and mice, respectively (Volkova, 1998).
Nerol
To evaluate the acute oral toxicity of nerol, ten male Wistar rats per dose were orally administered with doses of 2560, 4000, 6250 and 9800 mg/kg bw (Moreno, 1972). Since mortality was noted within the 14 day observation period, a LD50 of 4500 mg/kg bw was calculated.
Inhalation
Geraniol
The acute inhalative toxicity was analyzed in a study with rabbits which were exposed to a vapor of 1, 1.5, 3, 9, 27, 81 mg/ml geraniol in ethanol for four hours (Boyd, 1970). Since no mortality was observed, a LC0 of 81 mg/ml was determined.
In another study, five CF-1 mice were cannulated via the trachea and exposed for 1 min resulting in an ED25 value of 0.57 mg/l air (Troy, 1977).
Also a lowest toxic concentration (TCLo) of 0.5 mg/m3 air for rats was reported in a short report (Volkova, 1998).
Nerol
To analyze the acute inhalative toxicity of nerol, five CF-1 mice were cannulated via the trachea and exposed for 1 min with an aerosol (Troy, 1977). As a result an effective dose (ED) of 0.59 mg/l for nerol was found. However, due to limited exposure time, this study could not be taken for assessment.
Dermal
Geraniol
To determine the acute dermal toxicity 5000 mg/kg bw was applied to skin of three rabbits (Moreno, 1972). Since no mortality was noted during the 14 d observation time, the dermal LD50 was estimated as > 5000 mg/kg.
Nerol
Acute dermal toxicity was evaluated in a study, where pure nerol was applied under occlusion to the clipped abraded abdominal skin of ten New Zealand White rabbits (Moreno, 1972). Although one death occurred within the seven days observation period, a LD50 >5000 mg/kg bw was estimated.
Justification for classification or non-classification
Due to oral LD50 value of 3600 mg/kg for Geraniol and 4500 mg/kg for Nerol and a dermal LD50 >5000 mg/kg bw for both Geraniol and Nerol, the reaction mass was considered to have LD50 values in the same ranges and hence does not need to be classified for acute toxicity according to Regulation (EC) No 1272/2008.
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