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EC number: 230-939-3 | CAS number: 7378-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 01.04.1980 to 02.08.1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, not all details on single animla data reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- but quality assurance certificate
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl(octyl)amine
- EC Number:
- 230-939-3
- EC Name:
- Dimethyl(octyl)amine
- Cas Number:
- 7378-99-6
- Molecular formula:
- C10H23N
- IUPAC Name:
- dimethyl(octyl)amine
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): ADMA C8
- Physical state: clear liquid, specific gravity 0.76
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Nicholas Helf, Ace animals
- Age at study initiation: appr. 8 weeks
- Weight at study initiation: 2.3 to 2.8 kg
- Housing: Wire mesh cages 2 animals per cage
- Diet (e.g. ad libitum): fresh purina rabbit chow ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least one week
9 males, 7 females
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 21 deg. C
N-LIFE DATES: From: To:
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 200 cm2 (20% of body area)
- Type of wrap if used: guze patches wrapped with inpervious material.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): whiped (not washed) after 24 h exposure
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 3.0 to 74 ml
- Constant volume or concentration used: no - Duration of exposure:
- 24 h
- Doses:
- 1.0, 4.0, 16.0 and 20.0 g/kg bw
- No. of animals per sex per dose:
- 4 animals per dose. Sexes were not equally distributed.
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?) 14 days
- Frequency of observations and weighing:
Dermal examinations at 24 h (Draize scoring), daily observations for signs of toxicity, behavior and mortality
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight at the start and the end of the study. All animals in the high dose group were examined for gross pathological changes as well as all animals that died durign the study. - Statistics:
- Lichtfield Wilcoxon method for LD50 determination, 1949
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 1.500 to 10000 mg/kg bw
- Mortality:
- Dose Mortality
1 g/kg 0/4
4 g/kg 2/4
16 g/kg 4/4
20 g/kg 4/4 - Clinical signs:
- other: Skin reactions: Severe erythema and moderate oedema in all dose levels. the most common clinical sign was lethargy. Animals dying before day 14 had respiratory, cardiac and skin abnormalities.
- Gross pathology:
- Edematousl lungs i dilated heart n all animals of the high dose group, lun congestion and dilated heart in 4 animals of the 16 g/kg group. lung congestion in the two animals of the 4 g/kg bw group that died during the study.
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50, dermal rabbit was determined to be 4000 mg/kg bw. No deaths occurred at a dose level of 1000 mg/kg bw. Pronounced skin reactions, severe erythema and moderate edema were observed in all animals. Deaths occurred during the exposure period (day 0). According to the criteria of Regulation EC No. 1272/2008 and amendments the substance should not be classified for acute skin toxicity based on the results of this study.
- Executive summary:
Groups of 4 rabbits received dermal doses of 1, 4, 16 or 20g of test material per kg of body weights for a 24 h occlusive exposure period. Test material was wiped from the skin after the dosing period. The animals were observed for 14 days. The LD50 was determined to be 4000 mg/kg bw. Deaths occurred during the exposure period. According to the criteria of Regulation EC No. 1272/2008 and amendments the substance should not be classified for acute skin toxicity.
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