Registration Dossier
Registration Dossier
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EC number: 201-603-3 | CAS number: 85-41-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Phthalimide - CAS No: 85-41-6
- Author:
- OECD SIDS
- Year:
- 2 005
- Bibliographic source:
- SIDS Initial Assessment Report for 20th SIAM, UNEP Publications 2005
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
- Principles of method if other than guideline:
- One male animal (2.4 kg) was dosed with 5010 mg/kg bw and two animals (one male, 2.2 kg, and one female, 2.2 kg) were dosed with 7940 mg/kg bw for 24 hours, and observed for 14 days
- GLP compliance:
- no
Test material
- Reference substance name:
- Phthalimide
- EC Number:
- 201-603-3
- EC Name:
- Phthalimide
- Cas Number:
- 85-41-6
- Molecular formula:
- C8H5NO2
- IUPAC Name:
- 1H-isoindole-1,3(2H)-dione
- Details on test material:
- - Analytical purity: not indicated
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: 40% solution-suspension in corn oil
- Duration of exposure:
- 24 hours
- Doses:
- 5010 and 7940 mg/kg bw
- No. of animals per sex per dose:
- 1
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Remarks on result:
- other: rabbit
- Mortality:
- No mortality was observed
- Clinical signs:
- other: Animals showed reduced appetite and activity for one to two days
- Gross pathology:
- The viscera appeared normal at end of experiment (14 days)
Applicant's summary and conclusion
- Interpretation of results:
- not classified
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