Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-558-5 | CAS number: 108-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
There is no toxicokinetics, metabolism and distribution data available on diisopropylamine. Therefore, the assessment of the toxicokinetics of diisopropylamineis based on the available toxicological data and the physicochemical properties as suggested by the REACH Guidance Chapter R.7c:
Molecular weight: 101.2 g/mole
Water solubility: miscible
Partition coefficient log Kow = 0.4 at pH 12 and at 20°C
ABSORPTION
Oral route
According to the REACH Guidance, the physicochemical characteristics of diisopropylamine (log Pow 0.4) and the molecular mass (101.2 g/mol) are in a range suggestive of absorption as such from the gastro-intestinal tract subsequent to oral ingestion. This assumption of oral absorption is confirmed by the mortality observed from 250 mg/kg bw in the acute oral toxicity study in rats (Auletta, 1985) and the NOAEL of 50 mg/kg bw/d in the oral 4-week toxicity study in rats (Verschuere, 1991).
Therefore, the oral absorption of diisopropylaminecan be assumed to be 100% for risk assessment.
Inhalation route
According to the REACH Guidance, the physicochemical characteristics of diisopropylamine (log Pow 0.4) and the molecular mass (101.2 g/mol) are in a range suggestive of absorption as such from the respiratory subsequent to inhalation exposure. This assumption of absorption is supported by the results of the acute inhalation toxicity studies (BASF, 1979; Price et al., 1979). Therefore, the inhalation absorption can be assumed to be 100% for risk assessment.
Dermal absorption
According to the REACH Guidance, the n-Octanol/water partition coefficient (log Pow), the water solubility and molecular weight of diisopropylamine are in ranges which favour dermal absorption. This assumption of absorption is supported by the mortality observed at 5000 mg/kg in the acute dermal toxicity study in rats (BASF, 1977). In such circumstances, a default value of 100% skin absorption is generally used. However, when compared to the acute oral toxicity data, mortality by dermal administration was observed at a dose level 20 times higher, indicating a significant lower dermal absorption. A default value of 10% for skin absorption will be used for risk assessment.
DISTRIBUTION and METABOLISM
According to the REACH Guidance, as a small molecule a wide distribution of diisopropylamine is expected.
Diisopropylamine is predicted to be initially oxidized to acetone and either isopropylamine or N-hydroxy-isopropylamine. The actual predominant metabolic route of DIPA is unknown.
ELIMINATION
According to the REACH Guidance, the n-Octanol/water partition coefficient (log Pow of 0.4) is not suggestive of accumulation of unchanged diisopropylamine in fatty tissues subsequent to absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.