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EC number: 292-562-0 | CAS number: 90640-43-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No test data available. Profiling and QSARs indicate a low risk for sensitisation, and due to use in industrial and professional setting only, with the application of adequate PPE related to the severe corrosive properties of the diamines, exposures are limited. There are no reports on incidents of sensitisation to diamines available.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
The profiling of alkyl-diamines (QSAR Toolbox v.4.1) indicates that no alerts are found for protein binding, thiol reactivity is not expected, and that the structure is not represented among the categories of high, moderate or low reactivity in DPRA (direct peptide reactivity assays) for either cysteine or lysine depletion. Additionally, the molecular structure of the diamines does not contain toxicophores indicating a concern for sensitization, and also read across to data available on structurally related branched triamine (Dodecyl dipropylene triamine) and primary amines in general do not indicate a concern.
(The automated workflow in QSAR Toolbox for sensitisation results to a positive prediction, which is based on cross-reading to a single positive GPMT result from decanol, and a negative LLNA for 1,14-Tetradecanediol. As both substances are not even amine structures, this prediction is not considered valid)
Information from QSARs:
- VEGA (Skin Sensitisation model (CAESAR) version 2.1.6): Predicts sensitizer, but with low validity: it indicates that the substance is out of model Applicability Domain and that there are no similar compounds in the training set. (All listed positive structures are not amines)
- DEREK (Derek Nexus: 3.0.1, Nexus: 1.5.0): predicts that skin sensitisation is plausible. This is based on observation of sensitisation to diamine as diaminoethane, ethyleneamines and 3-aminopropyldimethylamine. These are not considered to be predictive to the cationic surfactant diamines.
- TOPKAT (Accelrys ADMET Toxicity Prediction (Extensible)) predicts non-sensitizer, with highest reliability for longer (C18) chain length.
There are no reports on incidences of sensitisation from industrial production and use of the substance.
For a comparable structure (C12-triamine Y) a guinea pig study (OECD 406 - Buehler) study is available, which confirms non-sensitizing properties. Also read-across to data derived from animal testing available for the structurally related primary amines do not indicate a concern.
(For information on the applicability of the read-across from various diamines, see document "Category polyamines - 20170518.pdf" added to IUCLID Ch. 13.)
As indicated under skin corrosion/irritation, the skin reactions have a large inflammatory component. These inflammatory reactions lead to local lymph node growth at extreme low concentrations, suggesting of a very potent sensitisation reaction, although the few available data involving guinea pig studies (on other cationic surfactants do not show increased reactions upon challenge. Finally, also for polyamine products used as biocide, there are no specific concerns for sensitisation following handling or use.
Discussion: dermal
There is no data on sensitisation available for N-C12,14 alkyl-1,3-diaminopropane (C12-14-diamine).
Available studies indicate that C12-14-diamine is highly corrosive.There are no consumer exposures, only industrial/professional use under circumstances involving the use of PPM following the classification as corrosive cat. 1B. Consequently, due to limited exposures, animal testing is not required.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
N-C12,14 alkyl-1,3-diaminopropane is a fluid/paste with mp of 27°C and has a low vapour pressure of 0.0015 Pa at 20°C. Its use is limited to industrial and professional users and does not involve the forming of aerosols, particles or droplets of an inhalable size. So exposure to humans via the inhalation route will be unlikely to occur.
Additionally, information from profiling for expected protein interaction and QSARs for sensitisation result to a low concern.
Justification for classification or non-classification
Based on limited exposures by dermal route (substance is severely corrosive) or by inhalation (very low vapour pressure) and a low concern based on profiling for expected protein interaction and QSARs for sensitisation, sensitisation is not expected to be an issue.
However, as a firm conclusion from a study with this compound is lacking, no definite conclusion might be drawn for classification purposes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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