Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 439-590-3 | CAS number: 12158-75-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Copper is an essential trace element, consumed via human nutrition at daily intakes rates of 0.9/2.2 mg Cu/day. Its essentiality relates to its presence in a large number of proteins in the human body. Homeostasis is controlled via a metallothionein-associated mechanisms.
Copper is predominantly absorbed via the gastrointestinal tract. Upon passage to blood plasma, copper is bound rapidly to serum albumin or transcuprein as transport proteins. Subsequent transport is directed primarily to the liver, the critical organ accounting for copper homeostasis. Excess copper is excreted primarily through the bile, or incorporate intoceruloplasmin for resecretion to blood.
The oral absorption rate varies between 20 and 75% (the balance being excreted via faeces), and appears to inversely related to dietary copper content. Absorption only occurs in the intestine, but also to a relevant extent in the stomach (Linder and Goode, 1991).
Reliable quantitative data on the extent of pulmonary and dermal absorption have not been reported. However, in a view of the ionic nature of copper ions, percutaneous absorption is not considered to be a relevant route of entry in the body (WHO, 1998).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
