2-chloro-6-fluoro-phenol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Adequacy of study:

other information

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Annex V B.1 tris.

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test animals

Species:

other: Rat,(Wistar)

Administration / exposure

Vehicle:

propylene glycol

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 200 mg/kg bw

Mortality:

Male: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3

Clinical signs:

Signs of toxicity related to dose levels:
No mortality occurred among males and females treated 200
mg/kg body weight. All females dosed at 2000 mg/kg were
found dead within 40 minutes post-treatment.


Lethargy was noted in all males dosed at 200 mg/kg on day 1
only. No clinical signs were noted among the females.

Gross pathology:

Effects on organs:
Macroscopic examination of the animals treated at 200 mg/kg
body weight at termination did not reveal any abnormalities.
Gray-white discolouration of the glandular mucosa in the
stomach was found in all females dosed at 2000 mg/kg at
macroscopic post mortem examination.

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU