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EC number: 202-288-5 | CAS number: 93-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
1-phentlyethyl acetate was determined to be not irritating to skin and the eye according to studies performed in line with Association of Food and Drug Officials of the United States, Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics (1959).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in accordance with generally accepted scientific principles, but incomplete reporting on results and discussion, which do not affect the quality of the relevant results. With the exception of the contact period, and testing on abraded skin, the guideline used shares the same basic principles as the OECD guideline 404. The use of an occlusive patch, a longer contact time (24 hours instead of 4) and abrading the skin would produce a result bias towards irritation and as such represents a worst case. As no irritation was induced during the study, the results are considered to be a true and accurate reflection of the effects of the test substance.
- Qualifier:
- according to guideline
- Guideline:
- other: Association of Food and Drug Officials of the United States, Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, 1959, pp 46-48
- Deviations:
- not specified
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material: 1-phenylethyl acetate
- Name of test material (as cited in study report): USA2850 Methyl Phenyl Carbinyl Acetate (styrallyl acetate) - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Weight at study initiation: 2-2.5 kg- Housing: in accordance with standard laboratory procedure- Diet (e.g. ad libitum): in accordance with standard laboratory procedure- Water (e.g. ad libitum): ad libitum
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Shaved, abraded and non-abraded sites were used
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- TEST SUBSTANCE- Amount applied: 0.5 mLThe test substance was applied to abraded and non-abraded skin at 4 sites (2 abraded, 2 non-abraded). The abrasions were minor incisions through the stratum corneum, but not sufficient deep to disturb the derma (not to produce bleeding).
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- Readings were made at 24, 48 and 72 hours after the prescribed exposure period.
- Number of animals:
- 6
- Details on study design:
- TEST SITE- Area of exposure: 1 inch patch- Type of wrap if used: The patches were secured in place with adhesive tape. The entire trunk of the animal was wrapped with rubberized cloth the entire 24-hour period of exposure. The animals are immobilised in an animal holder.SCORING SYSTEM:Evaluation of the skin reaction for erythema and edema was scored in line with the method followed.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24/48/72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- overall irritation score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within:
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation recorded during the course of the study.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the test, the test substance was not considered to be a skin irritant.
- Executive summary:
In a pre-GLP skin irritation study conducted in line with the Association of the Food and Drug Officials of the United States: Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics, 1959 pp 49-51, the test substance was determined not to be a skin irritant.
Reference
Table 2: Readings
24 hours 48 hours 72 hours Erythema Edema Erythema Edema Erythema Edema 1 NA 0 0 0 0 0 0 A 0 0 0 0 0 0 A 0 0 0 0 0 0 NA 0 0 0 0 0 0 2 NA 0 0 0 0 0 0 A 0 0 0 0 0 0 A 0 0 0 0 0 0 NA 0 0 0 0 0 0 3 NA 0 0 0 0 0 0 A 0 0 0 0 0 0 A 0 0 0 0 0 0 NA 0 0 0 0 0 0 4 A 0 0 0 0 0 0 NA 0 0 0 0 0 0 NA 0 0 0 0 0 0 A 0 0 0 0 0 0 5 A 0 0 0 0 0 0 NA 0 0 0 0 0 0 NA 0 0 0 0 0 0 A 0 0 0 0 0 0 6 A 0 0 0 0 0 0 NA 0 0 0 0 0 0 NA 0 0 0 0 0 0 A 0 0 0 0 0 0
A = abraded; NA = non-abraded
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in accordance with generally accepted scientific principles, but incomplete reporting on results and discussion, which do not affect the quality of the relevant results. Study was not performed to GLP. The guideline to which the study was performed is basically comparable to the OECD guideline 405.
- Qualifier:
- according to guideline
- Guideline:
- other: Association of the Food and Drug Officials of the United States: Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics, Baltimore, Maryland, 1959 pp 49-51
- Deviations:
- not specified
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material : 1-phenylethyl acetate
- Name of test material (as cited in study report): USA2850 Methyl Phenyl Carbinyl Acetate (styrallyl acetate) - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS- Weight at study initiation: 2.0-2.5 kg- Housing: in accordance with standard laboratory procedure- Diet (e.g. ad libitum): in accordance with standard laboratory procedure- Water (e.g. ad libitum): ad libitum
- Vehicle:
- not specified
- Controls:
- yes
- Amount / concentration applied:
- TEST SUBSTANCE- Amount applied: 0.1 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- Three rabbits were used in the 'no wash group' and three rabbits were used in the 'four-second wash group'.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE- Washing: The eyes of three rabbits were washed with 20 mL of lukewarm water four seconds post installation.- Time after start of exposure:SCORING SYSTEM: Please refer to field "Any other information on material and methods incl. tables" under the heading "Table 1: Scale of scoring ocular lesions"TOOL USED TO ASSESS SCORE: hand-slit lamp
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation noted in any of the animals during the course of the study.
- Other effects:
- Sting reaction noted upon application
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the test, the test substance was not considered to be an eye irritant.
- Executive summary:
In a pre-GLP eye irritation study conducted in line with the Association of the Food and Drug Officials of the United States: Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics, 1959 pp 49-51, the test substance was determined not to be an eye irritant.
Reference
Table 2: Eye irritation scores
Rabbit No. Hours Cornea A x B x 5 =IrisA x 5 = Conjunctivae (A + B + C) x 2 = Total score* No wash 1 24 0 0 0 0 0 0 0 48 0 0 0 0 0 0 0 72 0 0 0 0 0 0 0 2 24 0 0 0 0 0 0 0 48 0 0 0 0 0 0 0 72 0 0 0 0 0 0 0 3 24 0 0 0 0 0 0 0 48 0 0 0 0 0 0 0 72 0 0 0 0 0 0 0 Four-second wash 4 24 0 0 0 0 0 0 0 48 0 0 0 0 0 0 0 72 0 0 0 0 0 0 0 5 24 0 0 0 0 0 0 0 48 0 0 0 0 0 0 0 72 0 0 0 0 0 0 0 6 24 0 0 0 0 0 0 0 48 0 0 0 0 0 0 0 72 0 0 0 0 0 0 0
*Total score possible/animal/observation interval = 110
Note: sting reaction when applied to eye.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation
The key study (Posner, 1971) was performed in line with the Association of Food and Drug Officials of the United States, Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics (1959) pp 46-48, but not to GLP, with a sufficient level of detail to assess the quality of the study. The study was performed to a good standard in line with sound scientific principles and was assigned a reliability score of 2 in accordance with Klimisch (1997).
Eye Irritation
The key study (Posner, 1971) was performed in line with the Association of Food and Drug Officials of the United States, Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics (1959) pp 49-51, but not to GLP, with a sufficient level of detail to assess the quality of the study. The study was performed to a good standard in line with sound scientific principles and was assigned a reliability score of 2 in accordance with Klimisch (1997).
Justification for selection of skin irritation / corrosion endpoint:
Only one study available.
Justification for selection of eye irritation endpoint:
Only one study available.
Justification for classification or non-classification
Skin Irritation
The key study for skin irritation indicates that the test substance has no effect on skin irritation. Therefore the no classification is required in line with Directive 67/548/EEC and Regulation 1272/2008.
Eye Irritation
The key study for eye irritation indicates that the test substance has no effect on eye irritation. Therefore the no classification is required in line with Directive 67/548/EEC and Regulation 1272/2008.
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