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EC number: 500-537-5 | CAS number: 161075-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6 December 1995 to 26 December 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- OECD Guideline-conform study conducted under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1150 (Acute inhalation toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hexafluoropropene, oxidized, oligomers, reduced, fluorinated
- EC Number:
- 500-537-5
- EC Name:
- Hexafluoropropene, oxidized, oligomers, reduced, fluorinated
- Cas Number:
- 161075-00-9
- Molecular formula:
- R-O(C3F6O)m-R with R= - CF3, - C2F5, -CF2H
- IUPAC Name:
- 1,1,1,2,3,3-hexafluoro-2,3-bis(1,1,2,2,2-pentafluoroethoxy)propane; 1,1,1,2,3,3-hexafluoro-2-(1,1,2,2,2-pentafluoroethoxy)-3-(trifluoromethoxy)propane; 1,1,1,2,3,3-hexafluoro-3-(1,1,2,2,2-pentafluoroethoxy)-2-(trifluoromethoxy)propane; 1,1,1,2,3,3-hexafluoro-3-{[1,1,1,2,3,3-hexafluoro-3-(trifluoromethoxy)propan-2-yl]oxy}-2-(trifluoromethoxy)propane; 1,1,1,3,3,4,6,6,7,9,9,10,12,12,12-pentadecafluoro-4,7,10-tris(trifluoromethyl)-2,5,8,11-tetraoxadodecane; 1-(difluoromethoxy)-1,1,2,3,3,3-hexafluoro-2-(1,1,2,2,2-pentafluoroethoxy)propane; 2,2,3,5,5,6-hexafluoro-3,6-bis(trifluoromethyl)-1,4-dioxane; 2-(difluoromethoxy)-1,1,1,2,3,3-hexafluoro-3-(1,1,2,2,2-pentafluoroethoxy)propane
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): GALDEN HT 70
- Substance type: pure substance
- Physical state: liquid
- Analytical purity: >99%
- Impurities (identity and concentrations): not reported
- Composition of test material, percentage of components: not reported
- Isomers composition: not reported
- Purity test date: not reported
- Lot/batch No.: 3217RE
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: Room temperarture, in the original container.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: livestock farming
- Age at study initiation: about 8 weeks
- Weight at study initiation: males: 320-337 g, females: 216-246 g
- Fasting period before study: not reported
- Housing: 5 rat of same sex/cage. Cage size: 35cm x 53 cm x 25 cm, suspended on a movable rack.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days before the day of exposure
ENVIRONMENTAL CONDITIONS
- Temperature (°C): within the limit of 12°C - 22°C
- Humidity (%): betwen 36% and 53%
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12 hour cicle (8 a.m.-8 p.m.)
IN-LIFE DATES: From: To: not reported
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of atmosphere generation: The test atmosphere was generated by vaporising GALDEN LMW in a stream of air flowing through a heated coppel coil (vaporiser) immersed in a water bath. The test substance was delivered to the vaporiser at a constant flow rate from a stainless steel reservoir by a metering pump. The air supplied to the vaporiser was dried, filtered and oil free.
- Exposure apparatus: The test atmosphere entered through a port at the top of the chamber and passed out through a port in the base of the chamber.
- Exposure chamber volume: approximately 70 litres
- Description of exposure chambers: The whole-body exposure chambers used for the exposures were of square section and were fitted with pyramidal tops. The chambers were made of acrylic polymer. Each chamber was divided by wire mesh partitions to provide 10 separate animal compartements. Each chamber was positioned inside a large cabinet equipped with an extract fan exhausting to atmosphere through a collection filter.
The rats to be exposed were placed into separate compartments of the exposure chambers.
- Temperature in air chamber: 24 °C +- 0.6 (Test group), 23 °C +- 0.4 (Control group);
- Oxygen concentration in air chamber: 20% +- 0.2 (Test group), 20% +- 0.1 (Control group);
TEST ATMOSPHERE
- Brief description of analytical method used: Analysis was carried out by gas chromatography and standardised by using preparations of the test substance vapour in gas bags. (Pye Unicam PU4550 Gas Chromatograph fitted with gas injection valve; Detector: Flame Ionisation)
- Samples taken from breathing zone: Yes. Six air samples were taken from the chamber during the exposure. The air samples, obtained using a polypropylene syringe, were directed straight to the Gas Chromatograph.
VEHICLE
- Composition of vehicle (if applicable): air.
- Concentration of test material in vehicle (if applicable): 9.47 % (v/v) +- 0.623
- Lot/batch no. (if required): n.a.
- Purity: n.a.
PROCEDURE
The test material was pumped from the reservoir, mixed with a supply of clean dried air and passed through the vapour generator. The flow rate of test material was 14ml/minute and the air supply pressure was adjusted to give a flow rate of 14 litres per minute through the generator.
The pump and air supplies were switched on and the exposure time for 4 hours, following a 12-minute equilibration period (12 minutes is the theoretical time required for the concentration of vapour in the chamber to reach 90% of its final value under the conditions of exposure employed).
The control group was treated similarly but exposed to clean air only for 4 hours. The control rats were returned to the holding room at the end of the exposure procedure. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 9.47 % (v/v) +- 0.623 (target concentration : 10% v/v)
- No. of animals per sex per dose:
- 10 (5 males + 5 females)
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the rats were observed continuously for signs of reaction to the test substance during exposure and at least twice daily throughout the observation period. The clinical signs were recorded at the end of the chamber equilibration period, at 0.25, 0.5 and 1.0 hours and then at hourly intervals during the exposure. During the observation period the clinical signs were recorded once in the morning and then as necessary following a later check for clinical signs.
All rats were weighed daily from the day of delivery to the testing laboratory until the end of the observation period.
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs, body weight, lung weights, gross pathology.
Results and discussion
- Preliminary study:
- Not performed.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 94 700 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: analytical mean value
- Remarks:
- ppm (v/v)
- Mortality:
- There were no deaths in the group of rats exposed to the test material.
- Clinical signs:
- other: There were no clinical signs during the exposure or following exposure to the test material.
- Body weight:
- There were no effect on the rate of bodyweight gain for rats exposed to the test material.
- Gross pathology:
- There were no macroscopic abnormalities in test and control rats.
- Other findings:
- The lung weight to bodyweight ratio was within normal limit for all rats.
Any other information on results incl. tables
Food and water consumption was not affected by exposure to the test material.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute inhalation LC50 (4-hour) of GALDEN LMW to rats was in excess of 9.47% (v/v) in air.
Based on MW range 350-500 this is equivalent to 1355-1936 mg/L. - Executive summary:
The objective of this study was to establish the acute inhalation toxicity of Galden LMW to rats.
The study design was in compliance with the OECD guideline Method No. 403 and EEC guideline Method B2.
One group of five male and five female Sprague Dawley CD rats was exposed to an atmosphere containing 9.47% (v/v) of GALDEN LMW. Exposure was continuous for 4 hours using a whole body exposure system. An additional group of 5 males and 5 females acted as controls and were exposed to air only for 4 hours.
Animals were observed during the exposure period and for 14 days post exposure. Group food and water consumption were measured daily throughout. Each animal was subjected to post mortem examination.
There were no deaths following exposure to GALDEN LMW.
No clinical signs were observed during and after exposure.
Bodyweight gain for the rats exposed to GALDEN LMW was similar to that of the control rats.
Food and water consumption were no affected following exposure to GALDEN LMW.
Lung weight to bodyweight ratios for the rats exposed to GALDEN LMW were within normal limits.
There were no macroscopic abnormalities in rats exposed to GALDEN LMW.
In conclusion the acute inhalation LC50 (4-hour) of GALDEN LMW to rats was in excess of 9.47% (v/v) in air (corresponding to 1355 - 1936 mg/L).
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