Registration Dossier
Registration Dossier
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EC number: 938-774-5 | CAS number: 85408-49-7
Endpoint summary
Administrative data
Description of key information
Additional information
No aquatic toxicity studies have been performed using C12 -16 amine oxide. Data are read across from C12-14 and C12-18 AO on the basis of the equivalence in chemical structure, large overlap in chain length distributions between the substances and expected similarities in physico-chemical properties.
Fish: Rowlands (2005b) exposed Rainbow trout (Oncorhynchus mykiss) to C12-18 AO under semi static conditions for 96 hours in a GLP study performed according to OECD TG 203. The LC50 (96 h) was 1.26 mg AO/L, based on nominal concentrations.This is the lowest LC50 derived from the reliable studies available for C12-14 and C12-18 AO.
In a full life-cycle toxicity test (similar to EPA OPPTS 850.1500) fathead minnows (Pimephales promelas) were exposed to C12 -14 AO for 302 days under flow through conditions [Aquatic Environmental Services (1976) ]. The NOEC was 0.42 mg AO/L (mean measured concentration), based on reduced fry survival, reduced egg hatch, and occluded eyes in test fish.
Daphnia: Noack (2001b) exposed Daphnia magna to C12-18 AO under static conditions for 48 hours in a GLP study performed according to OECD TG202. The EC50 (48 h) was 2.4 mg AO/L.This is the lowest EC50 derived from the reliable studies available for C12-14 and C12-18 AO.
A 21-day survival and reproduction test with Daphnia magna following OECD TG 211 is available for C12-14 AO [Maki (1997) ]. The 21 -day NOEC was 0.70 mg AO/L, based on both survival and reproduction.
Algae: The 72-h ErC50 for algae of 0.146 mg AO/L is calculated as the geometric mean of the results from four reliable studies performed using C12-14 AO on Pseudokirchnerella subcapitata which appears to be the most sensitive algal species based on the available data.
The toxicity of C12-14 AO to algae was evaluated in a 28 -day freshwater periphyton microcosm assay [Belanger (1999)]. The No-Observed Effect Concentration (NOEC) of the substance to the periphyton community was determined to be >67 µg AO/L, the highest test concentration evaluated (mean measured concentration).
Microorganisms: Kolvenbach (1990a, b) exposed Pseudomonas putida to either C12-14 or C12 -18 AO for 18 hours in a Bringmann-Kohn test. The EC10, based on reduction in growth rate, was 24 or 29.8 mg AO/L, respectively.
Sediment-dwelling organisms: No studies are available, however risk characterisation using the equilibrium partitioning method indicates that the risk to sediment dwelling organisms is adequately controlled and there is no need for further refinement of the assessment through testing.
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