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EC number: 206-462-1 | CAS number: 345-78-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Four case reports on the sensitizing properties of pseudoephedrine were identified. In these studies postive patch testing showed that these patients where sensitized to pseudoephedrine.
Additional information
Four case reports on the sensitizing properties of pseudoephedrine were identified. In these studies postive patch testing showed that these patients where sensitized to pseudoephedrine.
In a case report (Downs 1998) sensitization to prilocaine and lignocaine may have occurred in a patient following the topical application of Emla cream to an already inflamed skin site. Several months later application of pseudoephidrine resulted in palpitations and a generalised red itchy eruption. Patch testing showed positive reactions to pseudoephedrine, lignocaine and prilocaine. The presence of a benzene ring and a distally-placed nitrogen molecule, surrounded by methyl groups, in lignocaine, prilocaine and pseudoephedrine, suggests some sharing of epitopes between all 3 chemicals. Therefore, sensitization to pseudoephedrine may be due to crosssensitization.
A case of pseudoephedrine-induced Acute Generalized Exanthematous Pustulosis (AGEP) is described (Mayo-Pampin 2006). 24-hours before admission to the hospital the patient ingested one tablet Rinoebastel containing ebastine (10 mg) and pseudoephedrine (120 mg). A patch test showed an intense positive result (++++) at 48 and 96 hours with Rinoebastel 2,5% and 5% in petrolatum, as well as with pseudoephedrine 1% in petrolatum. Epicutaneous tests with ebastinc 1 % and 2% in petrolaturn were negative.
In a case report, a 42 -year old woman had an adverse drug reaction to Vincigrip containing paracetamol, pseudoephedrine, chlorphenamine and several excipients (Padial 2003). Patch testing with both the commercial preparation Vincigrip and pseudoephedrine showed an intense positive result at 48 h, with erythema and papules that persisted for 96 h but the epicutaneous tests with other sympathomimetic drugs were negative. A biopsy of the positive epicutaneous reaction site with pseudoephedrine was performed and the mononuclear infiltrate was composed mainly of CD4+ T cells, although CD8+ lymphocytes were also present in significant numbers. Furthermore, there was also a strong positive staining for CD25 and CD45RO. A lymphocyte proliferation assays were performed in which peripheral blood mononuclear cells from the patient were cultured in the presence of different doses of pseudoephedrine and other sympathomimetic drugs. After 5 days of culture no specific cell proliferation was detected in response to pseudoephedrine or the different drug analogues tested.
A 44-year-old Caucasian woman was admitted with an acute generalized, blistering, erythrodermic dermatitis. 6 h prior to admission, she had taken a combination of acrivastine and pseudoephedrine hydrochloride (Benadryl Plus) (Millard 2003). A patch testing revealed an allergic reaction after 48 hours with Benadryl Plus, but no reaction to Benadryl and to the blue and white components of the Benadryl Plus capsule.
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