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EC number: 271-363-2 | CAS number: 68551-11-1 A complex combination of products produced by the distillation of products from the hydrogenation of butanal from the hydroformylation of propene. It consists predominantly of organic compounds such as aldehydes, alcohols, esters, ethers and carboxylic acids having carbon numbers in the range of C4-C32 and boiling in the range of approximately 143°C to 282°C (289°F to 540°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study incl. analytics
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Oxooel 740
- Physical state: Liquid/ yellowish, clear
- Analytical purity: Sum of identified hydroformylation products: 85.4 cor.-area-% several other components could be quantified (see report 09L00241 chapter 3): 13.5 cor.-area-% Sum of identified compounds: 98.9 cor.-area-%
- Lot/batch No.: TK285_20090716
- Expiration date of the lot/batch: 2010-07-16
-Water solubility: poorly soluble (information from sponsor). Soluble up to 100 mg/L in test media (observation of Ecotoxicology Lab)
- Stability under test conditions: stable under storage conditions over the exposure period.
- Storage condition of test material: The test substance was stored in a refrigerator, dry storage.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0, 0.32, 1.0, 3.2, 10, 32 mg/L as nominal concentrations based on test substance mass without correction for purity
- Samples were taken on the following days:
Interval / Week 1
Day 0 (fresh solutions)
Day 2 (fresh and 48 hour old test solution)
Day 5 (fresh and 72 hour old test solution)
Day 7 (48 hour old test solution)
Interval / Week 2
Day 12 (fresh solutions)
Day 14 (48 hours old test solutions)
Interval / Week 3
Day 19 (fresh solutions)
Day 21 (48 hours old test solutions)
- Sample storage conditions before analysis: Sample transport to the Analytical Laboratory was done on the day of sampling. Storage at room temperature. The retained samples were stored in a refrigerator until sent to the analytical laboratory.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
The test item was homogenized by shaking the container before use and all test solutions were prepared individually (differential loading). The test substance is weighed, placed in a volumetric flask and filled to the mark with test medium and closed with a glass stopper. The solution was stirred for approximately 30 min at 20 ± 2 °C and visually checked for any undissolved test substance. All stock solution appeared colorless-clear
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna STRAUS
- Source: The clone of Daphnia magna STRAUS 1820 used was supplied by the Institut National de Recherche Chimique Appliquée, France, in 1978.
From this date on this clone was cultured and bred continuously in the Laboratory of Ecotoxicology of the Experimental Toxic
- Body length of parent animals: 4.4 mm before exposure
- Feeding during test: During the test daphnids were fed daily a diet of live green algae Desmodesmus subspicatus, cultured in a synthetic medium. The algae were separated from their culture medium by centrifugation, resuspended in daphnid's medium (M4) corresponding to concentrations of 1110 mg and 1160 mg TOC*/L (respectively) in the algal concentrates used. The daphnids were fed a defined volume (≤180 μL) of the concentrate to reach the amount of food defined in the table below. The algae were stored in a refrigerator (dark, about 4-8°C) for maximum 21 days.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Test conditions
- Hardness:
- 2.46-2.52 mmol/L
- Test temperature:
- 20°C
- pH:
- 8.0-8.6
- Dissolved oxygen:
- 8.4-9.2
- Nominal and measured concentrations:
- Concentrations: 0, 0.32, 1.0, 3.2, 10, 32 mg/L as nominal concentrations based on test substance mass without correction for purity
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Numbered glass beakers (nominal volume 50 mL), sealed with ground glass stoppers. The test vessels were sealed and completely filled due to the volatility of the test substance.
- Material, size, headspace, fill volume: approx. 50 mL
- Type (delete if not applicable): closed
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): 3 times per week
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10 (10 replicates)
- No. of vessels per control (replicates): 10 (10 replicates)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: A synthetic fresh water (Elendt M4) is used as media for culture and test purposes. For the composition of this M4 medium see OECD 211.
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: pH value: 7.5 – 8.5
- Photoperiod: 16 hours light : 8 hours darkness
- Light intensity: About 631 - 706 lux at a wave length of 400 -750 nm
(recommended values in lux units provided in ISO 10706)
- Exposure conditions: Semi-static exposure via test water
VEHICLE CONTROL PERFORMED: no - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality of parent animals: 30% in the highest test group (32 mg/L) after 21 days of exposure
- Reproduction: 46% in the highest test group (32 mg/L) after 21 days of exposure
- Body length of parent animals: 4.4 mm before exposure, 4.2 mm in the highest test group (32 mg/L) after 21 days of exposure
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A significant effect on parent mortality and reduced reproductive output was observed in the highest test group (32 mg/L) after 21 days of exposure. In addition a significant effect on parent growth (as length) was also observed in the highest test group. As effects were only observed in the highest test group, ECx point estimates could not be reliably calculated.
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