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EC number: 256-881-9 | CAS number: 50977-10-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Etheramine C13i was found to be corrosive in BCOP test, and corrosive to rabbit skin follwing 3 minutes exposure.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Etheramine C13i induced severe ocular irritation on isolated bovine cornea through, resulting in a mean in vitro irritancy score of 82 after 10 minutes of treatment. As the IVIS is above 55.1, it this means that Etheramine C13i is corrosive or severe irritant in the Bovine Corneal Opacity and Permeability test.
There is a Japanese publication on the dermal effects performed with a linear C12-etheramine (3-(Dodecyloxy)propylamine; CAS 7617-74-5) [Nakano Y, 1995] in an in vivo dermal corrosion study on rabbit skin which indicated that 3-lauryl oxy propylene amine is not corrosive. However, the available English translation is very poor in reporting. Also there is doubt on the product tested, as this is described as a solid with a mp of about 65°C, whereasEtheramine C13i is a clear fluid with a mp < -30°C.
ref.: Nakano Y, 1995, Corrositex evaluation on amino compound and pyridino compound, Osaka Prefectural Institute Public Health, Osaka, Japan
Etheramine C13i was tested in an in vitro skin irritation test using a reconstructed human epidermis model (EU method B.46). However, as the substance caused anon-specific MTT reduction > 30% (39% & 41%), it was conclude that this method is not a suitable test method for Etheramine C13i.
Results from the BCOP study indicated that severe effects could be expected following dermal exposure, but as the in vitro dermal irritation study was not technical feasible, an in vivo study was designed specifically to minimize the risk for animal harm. The study was performed in a stepwise manner and started with the treatment of one animal with a stepwise exposure regime.
One rabbit was exposed to three samples of 0.5 mL of Etheramine C13i applied to separate skin-sites on intact, clipped skin using a semi-occlusive dressing. The exposure periods were 3 minutes, 1 hour and 4 hours, respectively. Skin reactions were assessed at least once daily for 4 days after treatment and 7 and 14 days after exposure. Based on the severity of the skin reactions, no further animals were exposed.
All exposures resulted up to very slight erythema and oedema in the treated skin areas on day 1, progressing into severe erythema and oedema from 24 hours after exposure on all treated skin sites. The skin irritation remained present up the end of the 14-day observation period and was accompanied by reduced flexibility of the skin between 24 hours and 7 days. A dry wound as well as a bald, noticeable white skin (indicating full thickness destruction of the skin), and superficial redbrown eschar formation was observed at 14-days after exposure on all treated skin sites.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
The in vivo dermal corrosion study in rabbits, indicates that Etheramine C13i causes corrosive effects of the skin following 3 minutes exposure, which developed with the course of a week. Consequently, GHS classification 1B is appropriate, with hazard statement H314: Causes severe skin burns and eye damage.
There is no information is available following exposure via inhalation. However, with a vapour pressure of 0.425 Pa at 20 °C, potential for inhalation of vapours is limited. Inhalation of aerosols may cause respiratory irritation due to the corrosive properties of the substance.
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