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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR toolbox
Title:
QSAR Study for 121-57-3
Year:
2011
Bibliographic source:
OECD QSAR toolbox version 2.2, 2011; : Unilever (LMC,BUL);2002

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
QSAR estimation database
GLP compliance:
not specified
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Reference substance name:
Sulphanilic acid
EC Number:
204-482-5
EC Name:
Sulphanilic acid
Cas Number:
121-57-3
IUPAC Name:
4-aminobenzenesulfonic acid

In vivo test system

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Induction
Route:
other: no data
Vehicle:
unchanged (no vehicle)
Challenge
Route:
other: no data
Vehicle:
unchanged (no vehicle)

Study design: in vivo (LLNA)

Vehicle:
unchanged (no vehicle)

Results and discussion

In vivo (LLNA)

Results
Parameter:
other: Migrated information from in vivo LLNA study
Remarks on result:
other: Reading: 1st reading. Group: test group. No with. + reactions: 0.0. Clinical observations: Negative.

Any other information on results incl. tables

Skin sensitization = Negative

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Skin sensitisation : Negative
Executive summary:

Since both the read across substances indicate that skin sensitisation is negative so the target chemical is also considered as negative skin sensitization.