Registration Dossier
Registration Dossier
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EC number: 203-139-7 | CAS number: 103-73-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Monographs on Fragrance Raw Materials
- Author:
- D. L. J. OPDYKE F
- Year:
- 1 979
- Bibliographic source:
- Food & cosmetic toxicology . Vol 17. pp 241 to 275
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Not available
- GLP compliance:
- not specified
- Test type:
- other: No data
Test material
- Reference substance name:
- Anisole
- EC Number:
- 202-876-1
- EC Name:
- Anisole
- Cas Number:
- 100-66-3
- Molecular formula:
- C7H8O
- IUPAC Name:
- methoxybenzene
- Test material form:
- not specified
- Details on test material:
- Not available
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Details not available
- Duration of exposure:
- Details not available
- Doses:
- Details not available
- No. of animals per sex per dose:
- Details not available
- Control animals:
- not specified
- Details on study design:
- Details not available
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Non toxic
- Mortality:
- Details not available
- Clinical signs:
- other: Details not available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A dermal LD50 study was conducted in which 5000 mg/kg of Anisole was applied to the skin of rabbits. The animals were observed for mortality and/or systemic effects for 14 days. No further details were provided. Acute dermal LD50/rabbits > 5000 mg/kg bw was determined.
- Executive summary:
A dermal LD50 study was conducted in which 5000 mg/kg of Anisole was applied to the skin of rabbits. The animals were observed for mortality and/or systemic effects for 14 days. No further details were provided. Acute dermal LD50/rabbits > 5000 mg/kg bw was determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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