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EC number: 271-208-9 | CAS number: 68526-52-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restrictions because it was conducted according to GLP guidance and OECD 405 guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alkenes, C6-8
- IUPAC Name:
- Alkenes, C6-8
- Details on test material:
- - Name of test material (as cited in study report): SHOP C68 Internal Olefin
- Substance type: Alkenes, C6-8
- Physical state: Liquid (clear, colourless)
- Lot/batch No.: 168082
- Storage condition of test material: Cool conditions (not exceeding 13 degrees C), under nitrogen, protected from light, in original container
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Froxfield SPF Rabbits, Broadway Farm, Froxfield, Hampshire, England.
- Age at study initiation: Approximately 4 months old
- Weight at study initiation: 2.8 to 3.35 kg
- Housing: Individually in suspended stainless steel cages mounted in mobile batteries. The cages were fitted with perforated countersunk floor panels. A tray beneath the floor was lined with absorbent paper which was changed at regular intervals.
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Health status of each animal was monitored and a record kept. Both eyes of all animals were examined before administration of test material for signs of pre-existing irritation, reaction or abnormality which would prevent it from being used in this study.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 to 19
- Humidity (%): 38 to 60
- Air changes (per hr): At least 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL single dose - Duration of treatment / exposure:
- Dose was instilled into the right eye by pulling the lower eyelid away from the eyeball to form a cup into which the test material was dropped. The eyelids were gently held together for 1 second and then released.
- Observation period (in vivo):
- 1, 24, 48, and 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): None
TOOL USED TO ASSESS SCORE: Opthalmoscope or pencil beam torch was used to facilitate inspection of the eyes.
Fluorescein was used from the 24-hour period onward to aid cornea examination.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- corneal opacity
- Basis:
- mean
- Time point:
- other: 24,48, and 72 hours
- Score:
- 0
- Irritation parameter:
- other: Iridial lesions
- Basis:
- mean
- Time point:
- other: 24,48, and 72 hours
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness of conjunctivae
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0.2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24,48, and 72 hours
- Score:
- 0
Any other information on results incl. tables
Grade for Ocular Irritation Responses
Animal No. and Sex: 498F |
Pain Evaluation Response: 1 |
||||
Region of the Eye |
Response |
Grade of Response at time after instillation (hours) |
|||
1 |
24 |
48 |
72 |
||
Cornea |
Opacity |
0 |
0 |
0 |
0 |
Area |
0 |
0 |
0 |
0 |
|
Ulceration |
- |
- |
- |
- |
|
Stippling |
- |
- |
- |
- |
|
Iris |
Value |
0 |
0 |
0 |
0 |
Conjunctiva |
Redness |
2 |
0 |
0 |
0 |
Chemosis |
1 |
0 |
0 |
0 |
|
Discharge |
1 |
0 |
0 |
0 |
|
Necrosis |
- |
- |
- |
- |
|
Ulceration |
- |
- |
- |
- |
Animal No. and Sex: 28TD786F |
Pain Evaluation Response: 1 |
||||
Region of the Eye |
Response |
Grade of Response at time after instillation (hours) |
|||
1 |
24 |
48 |
72 |
||
Cornea |
Opacity |
0 |
0 |
0 |
0 |
Area |
0 |
0 |
0 |
0 |
|
Ulceration |
- |
- |
- |
- |
|
Stippling |
- |
- |
- |
- |
|
Iris |
Value |
0 |
0 |
0 |
0 |
Conjunctiva |
Redness |
1 |
1 |
1 |
0 |
Chemosis |
0 |
0 |
0 |
0 |
|
Discharge |
0 |
0 |
0 |
0 |
|
Necrosis |
- |
- |
- |
- |
|
Ulceration |
- |
- |
- |
- |
Animal No. and Sex: 28TD799F |
Pain Evaluation Response: 1 |
||||
Region of the Eye |
Response |
Grade of Response at time after instillation (hours) |
|||
1 |
24 |
48 |
72 |
||
Cornea |
Opacity |
0 |
0 |
0 |
0 |
Area |
0 |
0 |
0 |
0 |
|
Ulceration |
- |
- |
- |
- |
|
Stippling |
- |
- |
- |
- |
|
Iris |
Value |
0 |
0 |
0 |
0 |
Conjunctiva |
Redness |
1 |
0 |
0 |
0 |
Chemosis |
1 |
0 |
0 |
0 |
|
Discharge |
0 |
0 |
0 |
0 |
|
Necrosis |
- |
- |
- |
- |
|
Ulceration |
- |
- |
- |
- |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this test, SHOP C68 is considered to be a non-irritant to the eye.
- Executive summary:
In a primary eye irritation study, 0.1 mL of SHOP C68 internal olefin was instilled the conjunctival sac of the right eye in 3 New Zealand White rabbits. Animals then were observed at 1, 24, 48, and 72 hours. Irritation was scored by the guidelines.
Initial instillation of the test compound caused very slight initial pain response. All animals had very slight to slight conjunctivitis within an hour of treatment, but one animal showed persistent response at 48 hours. At 72 hours, all animals’ eyes appeared normal.In this study, SHOP C68 internal olefin is a non-irritant to the eye.
This study received a Klimisch score of 1 and is classifiedas reliable without restrictions because it was conducted according to GLP guidance and OECD 405 guidelines.
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