Alkenes, C13-14, hydroformylation products, low boiling

Short-term toxicity to fish

Description of key information

The short-term toxicity in fish of components of Alchisor TAL 145 has been documented within this dossier.  Adequate reliable measured data exists for short-term toxicity to fish to components of Alchisor TAL 145 (namely, Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), tetradecan-1-ol and dodecan-1-ol).  In a protective approach the most sensitive study result from across the three constituents has been identified and used to address the hazard endpoint in question. The most sensitive study result from across the three substances has been identified as a reliable study with dodecan-1-ol (Veith, 1983) which reports an LC50 for short term toxicity in fish of 1.01mg/L. This study was the lowest measured definitive result across the three Alchisor TAL 145 components.  Consequently this value will be taken as the short-term toxicity in fish endpoint for Alchisor TAL 145. 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

1.01 mg/L

Additional information

Alchisor TAL 145 can be characterised according to three constituents: Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), tetradecan-1-ol and dodecan-1-ol. Study data, where available, for each constituent has been evaluated and considered together. Several reliable (Klimisch 1 or 2) short-term toxicity studies in fish have been conducted for constituents of Alchisor TAL 145 (namely, Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), tetradecan-1-ol and dodecan-1-ol) and are included in this dossier. The reliable studies included for each constituent of Alchisor TAL 145 is briefly described below. In a protective approach the most sensitive study result from across the three constituents will be identified and used to address the hazard endpoint in question.

 

Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)

Two reliable (Klimisch 1) short-term toxicity studies for fish were available for Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) both of which are provided by Shell Research and Technology Centre. In the first the Shell Research and Technology Centre (1995) conducted a reliable (Klimisch 1) GLP compliant OECD 203 study with low aromatic white spirit (identified as hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)). The 96-hr LL50 for fish was 10 -100 mg/l. In the second study, the Shell Research and Technology Centre (1997) conducted a reliable (Klimisch 1) GLP compliant OECD 203 study with low aromatic white spirit (identified as hydrocarbons, C10-C13, C8-C12 & C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)). The 96-hr LL50 for fish was 10 -30 mg/l, which is the most sensitive result from the two reliable short-term studies for Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%).

 

Dodecan-1-ol

Two reliable (Klimisch 2) short-term toxicity studies for fish were available for dodecan-1-ol.  The acute toxicity of Kalco 2098 (i.e. dodecan-1-ol) to rainbow trout (Oncorhynchus mykiss) was reported by Wetton (1996) in an OECD 203 guideline GLP compliant study where the 96hr LC50 was reported as >1mg/L. Veith (1983) provided short-term toxicity results for exposure of dodecan-1-ol to the fish,Pimephales promelas. Dodecan-1-ol was administered at 5 nominal concentrations in a range pre-determined to obtain 0 and 100% mortality (specific dose regimen not reported). The 96hr LC50 was calculated using the trimmed Spearman-Karber method at 1.01 mg/L for dodenca-1-ol. This study result is the most sensitive result from the two reliable short-term studies with dodecan-1-ol.

 

Tetradecan-1-ol

Three reliable (Klimisch 2) short-term toxicity studies for fish were available for tetradecan-1-ol. These include studies by Steller (date unknown), Fisk et al., (2010), and Wetton (1996). Steller (date unknown) reported a 96hr LC50 to be >10,000 mg/L for exposure ofDanio riroto tetradecan-1-ol. Fisk et al., (2010) provided an estimate of short term toxicity of tetradecan-1-ol which was predicted using a multiple partitioning model where the predicted LL50 is >0.19 mg/L. Wetton (1996) provided short-term toxicity results for exposure to tetradecan-1-ol to the fish,Oncorhynchus mykiss,which included a 96 hr LC50 of > 1.0 mg/L.This data is the most sensitive measured result of the three reliable short-term studies tetradecan-1-ol.

 

The short-term toxicity in fish of components of Alchisor TAL 145 has been documented within this dossier. Adequate reliable measured data exists for short-term toxicity to fish to components of Alchisor TAL 145 (namely, Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), tetradecan-1 -ol and dodecan-1 -ol). In a protective approach the most sensitive study result from across the three constituents has been identified and used to address the hazard endpoint in question.The most sensitive study result from across the three substances has been identified as a reliable study with dodecan-1-ol (Veith, 1983) which reports an LC50 for short term toxicity in fish of 1.01mg/L. Consequently this value will be taken as the short-term toxicity in fish endpoint for Alchisor TAL 145.