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EC number: 213-701-3 | CAS number: 1003-14-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
not irritating to the skin (BASF AG, 1982, OECD404)
irritating to the eye (BASF AG, 1982, OECD405)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation corrosion:
The potential of n-Pentenoxide-1,2 to induce skin irritation was tested according to OECD guideline 404. Three White Vienna rabbits were shaved and the appropriate skin sites treated with the test item for 4 h using semi-occlusive dressing. Rabbits were monitored for 8 days and the severity of skin lesions evaluated according to the Draize scoring system. The mean erythema score for the three rabbits after 24, 48 and 72 h was 0.67 and the edema score 0.1. Erythema was fully reversible within 48 h (2 animals) or 8 days (1 animal), respectively. Accordingly, edema was fully reversible within 24 h (2 animals) or 48 h, respectively. No other clinical findings (including organ changes) were observed by the end of the treatment. It can therefore be concluded that 1,2 -Pentenoxid is not irritating.
Eye irritation/corrosion:
The potential of n-Pentenoxide-1,2 to induce eye irritation/corrosion was analyzed according to OECD guideline 405. One eye of three White Vienna rabbits was treated with 100 µl of the undiluted test item; the untreated eyes served as controls. Substance was not washed out the next day. Rabbits were observed for 8 days and eye lesions recorded according to the Draize scheme. The following mean scores for the three animals were noted after (mean score for 24, 48 and 72 h readings):
Cornea score: 0.67 (fully reversible within 8 days; however, for 2 of 3 animals, the mean score after 24, 48 and 72 h was 1)
Iris score: 0
Conjunctivae score: 1.57 (fully reversibly within 8 days)
Chemosis Score: 0.33 (fully reversible within 72 h)
Due to the mean cornea score which is >= 1 in 2 of 3 rabbits, but fully reversible within eight days, the substance has to be classified as irritating to the eyes.
Justification for selection of skin irritation / corrosion endpoint:
No skin irritating monitored in an OECD guideline 404 study
Justification for selection of eye irritation endpoint:
Moderate skin irritation observed in 2 of 3 rabbits in an OECD guideline 405 study
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
According to the classification criteria laid down in Council Directive 67/548/EEC (and subsequent adaptations) the test substance does not require skin and eye classification.
However, according to Regulation (EC) No 1272/2008 (CLP), the test item does not require skin labelling but is classified as eye category 2 and labelled with "Warning" and H319.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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