Registration Dossier
Registration Dossier
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EC number: 617-349-5 | CAS number: 82543-17-7
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Estimation based on structural similarity with test item for which hydrolysis study was performed.
- GLP compliance:
- no
Test material
- Reference substance name:
- 21a-Homo-6 alpha,7 alpha,15 alpha,16 alpha-tetrahydro-bis-3' H-cyclopropa[1',2':6,7;1'',2'':15,16]-5 beta,17 alpha-pregn-20-yne-3 beta,5,17,21a-tetrol
- EC Number:
- 617-349-5
- Cas Number:
- 82543-17-7
- Molecular formula:
- C24 H34 O4
- IUPAC Name:
- 21a-Homo-6 alpha,7 alpha,15 alpha,16 alpha-tetrahydro-bis-3' H-cyclopropa[1',2':6,7;1'',2'':15,16]-5 beta,17 alpha-pregn-20-yne-3 beta,5,17,21a-tetrol
- Test material form:
- solid: bulk
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- no
- Estimation method (if used):
- Estimation based on similarity of chemical structure with test substance for which hydrolysis study was performed and which was found to be hydrolytically stable.
Results and discussion
- Transformation products:
- no
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
The test substance does not contain functional groups which are susceptible to hydrolytic degradation. Hydrolytic stability is thus to be expected. This notion is experimentally supported by the results of a hydrolysis study with 17b-Hydroxy-17a-(3-hydroxy-1-propynyl)-4-androsten-3-one (ZK 4829) which is structurally similar to the test substance. ZK 4829 was found to be hydrolytically stable in the pH region 4 - 9 and 25 °C (see Schering report NJ16).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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