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EC number: 217-775-8 | CAS number: 1951-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Piperazine (CAS No 110-85-0) is the parent molecule from which piperazine, compound with phosphoric acid or piperazine phosphate (CAS No 1951-97-9) is synthesized. In medicine piperazine is used in the form of the hexahydrate or as the citrate, tartrate, phosphate (1951-97-9) or adipate. Thus, piperazine and piperazine phosphate can be considered as belonging to the same category.
Data source
Reference
- Reference Type:
- publication
- Title:
- BASF, Gewerbehygiene und Toxikologie, 1980
- Author:
- BASF
- Year:
- 1 980
- Bibliographic source:
- Gewerbehygiene und Toxikologie, 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard method for inhalation toxicity
- GLP compliance:
- no
- Test type:
- other: 14 day study (test comp
Test material
- Reference substance name:
- Piperazine
- EC Number:
- 203-808-3
- EC Name:
- Piperazine
- Cas Number:
- 110-85-0
- IUPAC Name:
- piperazine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Piperazine chips were filled in a glass flask, and placed in a water bath at 20oC. Air was flown through the chips at a rate of 200 l per hour. The air stream, wit dust particles and volatile piperazine, was passed through glass chambers with rats, in total 12 animals. The exposure time was 3, 10, 30 minutes, 1, 3 or 7 hours. The animals were observed for 14 days after the test.
- Duration of exposure:
- > 2 - < 420 min
- Concentrations:
- Details not available
- No. of animals per sex per dose:
- Total number of animlas - 12
- Control animals:
- not specified
- Details on study design:
- Piperazine chips were filled in a glass flask, and placed in a water bath at 20oC. Air was flown through the chips at a rate of 200 l per hour. The air stream, with dust particles and volatile piperazine, was passed through glass chambers with rats, in total 12 animals. The exposure time was 3, 10, 30 minutes, 1, 3 or 7 hours. The animals were observed for 14 days after the test.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- other: death and other respiratory irritation symptoms
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: No animals died and no symptoms were found at autopsy.
- Mortality:
- There was no mortality during the entire duration of test
- Clinical signs:
- other: No clinical symptoms observed at autopsy
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The chemical piperazine was not found to be acutely toxic by the inhalation route in the 7 hours study conducted with Rats
- Executive summary:
The chemical piperazine was not found to be acutely toxic by the inhalation route in the 7 hours study conducted with Rats
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