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Physical & Chemical properties

Vapour pressure

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Meets the requirements of GLP. There are no deviations from the recommended guideline.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
static method
Key result
Temp.:
20 °C
Vapour pressure:
443 Pa
Key result
Temp.:
25 °C
Vapour pressure:
508 Pa

Three measurement series were performed. The first measurement series was made using the effusion method. This method didn’t yield utilisable results, as the vapour pressure of the test item was much too high for this method. Therefore, a study plan amendment was issued, and the static method was employed. In the second measurement series, the static method was used, but due to an instrumental failure, no reliable values could be determined. Therefore, a new manometer (calibrated by DKD) was bought, and the measurement series were repeated with the new instrument. The third measurement series comprised two experiments. In the first experiment, the deviation between measurement at increasing and at decreasing temperatures was too high. Therefore, a second experiment was conducted. In this experiment, the vapour pressure of the test item was determined as 443 Pa at 20.0 °C, and 508 Pa at 25 °C.

Conclusions:
Using the static method, vapour pressures of 443 Pa at 20 ºC and 508 Pa at 25 ºC were determined.
Executive summary:

The vapour pressure of the test substance was determined according to OECD guideline 104 and EU method A.4. First, the effusion method was employed. The vapour pressure of the test item lay outside the determination limits of this method. Therefore, a study plan amendment was issued, and the static method was employed. Using the static method, vapour pressures of 443 Pa at 20 °C and 508 Pa at 25 ° C were determined. These values were calculated from the regression of 22 individual measurements.

 

Description of key information

Key study: Experimental result: Test according to OECD guideline 104 and EU Method A.4. GLP study.

Using the static method, vapour pressures of 443 Pa at 20 ºC and 508 Pa at 25 ºC were determined.

Key value for chemical safety assessment

Vapour pressure:
508 Pa
at the temperature of:
25 °C

Additional information

Key study: Experimental result: Test according to OECD guideline 104 and EU Method A.4.

Using the static method, vapour pressures of 443 Pa at 20 ºC and 508 Pa at 25 ºC were determined.