Registration Dossier
Registration Dossier
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EC number: 203-552-2 | CAS number: 108-12-3
Endpoint summary
Administrative data
Description of key information
No data is available for isovaleryl chloride. However, the toxicological profile of the non-branched isomer valeryl chloride and isovaleryl chloride are very similar. Due to their reactivity both acid chlorides react locally with human tissue at the port of entry and/or hydrolyze to form hydrochloric acid and valeric acid or isovaleric acid. There is an skin irritation/skin corrosion study available for valeryl chloride which can be used for the assessment of isovaleryl chloride.
Valeryl chloride was found to be highly corrosive to the rabbit skin under semiocclusive conditions. Dermal application for 3 minutes and 1 hour caused full thickness necrosis.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
No data is available for isovaleryl chloride. There is an skin irritation/skin corrosion study available for valeryl chloride which can be used for the assessment of isovaleryl chloride.
Skin irritation
Valeryl chloride was applied to the skin of one New Zealand White rabbit for 3 minutes and 1 hour under semiocclusive conditions in a GLP compliant OECD guideline 404 study (BASF AG, 1997). Full thickness necrosis was observed at 1 and 24 hour after patch removal at both exposure durations and erythema and edema (scores of 2 and 3) were observed beyond the area of exposure. Therefore, the study was terminated after 24 hours. Valeryl chloride was judged highly corrosive to the skin.
Eye irritation
In accordance with column 2 of REACH Annex VII, no testing on eye irritation is necessary as the substance is classified as corrosive to the skin according to Directive 67/548/EEC (C, R35) and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 (H314, Category 1A).
Effects on skin irritation/corrosion: highly corrosive
Effects on eye irritation: highly corrosive
Justification for classification or non-classification
Based on the available data, valeryl chloride needs to be classified according to Directive 67/548/EEC (C, R35) and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 (Category 1A, H314).
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