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EC number: 233-653-7 | CAS number: 10294-26-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-10-09 to 1990-10-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline study. At the time of the study conduct, GLP was not compulsory . However, the study was conducted in accordance with the principles of GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 1981-05-12
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Disilver(1+) sulphate
- EC Number:
- 233-653-7
- EC Name:
- Disilver(1+) sulphate
- Cas Number:
- 10294-26-5
- Molecular formula:
- Ag.1/2H2O4S
- IUPAC Name:
- disilver(1+) sulfate
- Details on test material:
- - Name of test material (as cited in study report): silver (I) sulphate
- Physical state: white, crystalline powder
- Storage condition of test material: closed container at room temperature, protected against light
- pH value: approx. 7
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: white russian (albino)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 8-9 months
- Weight at study initiation: 2.54-2.80 kg
- Housing: stainless steel cages with grating floor, type ASTA, size: 48.5x40x36.5 cm (LxBxH), supplied by ASTA Pharma AG, 4800 Bielefeld, Germany; individually housing
- Diet: approx. 120 g/day x animal standard diet, ssniff K, special diet for rabbits, supplied ny ssniff Spezialfutter GmbH, 4770 Soest, Germany
- Water: ad lipidium; drinking water quality from the Stadtwerke Bielefeld
- Acclimation period: 1 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5 - 24.0
- Humidity (%): 40 - 70
- Photoperiod: 12 hours dark/light cycle
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g test item was given to the dorsal skin area.
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.14 mL demineralised water per 0.5 g test material. - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after removal of the patches, thereafter once daily: 2 animals were observed for 3 days after application and in 1 animal for 5 days after application.
- Number of animals:
- 3 females
- Details on study design:
- TEST SITE
- Area of exposure: the application sites were clipped free of hair one day before treatment.Test substance was placed on the shorn dorsal skin area between shoulder and sacrum.
- Type of wrap if used: The site of application was covered with a linen cloth (approx. 6.25 cm2) which adhered to a synthetic film glue. A bandage
wrapped several times around the trunk (Acrylastic, No. 2408, width 8 cm; supplied by P. Beiersdorf and Co. AG, Hamburg) provided a complete occlusion.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After the end of the exposition time remaining test material was gently washed off as far as possible.
SCORING SYSTEM: The treated skin area was assessed qualitatively (erythema/eschar resp. edema) and quantitatively (values 0-4) using the DRAIZE scale. In addition, attention was paid to the occurrence of further reactions on the skin (e.g. corrosive effects) and to clinical symptoms (systemic toxic effects).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 5 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritant / corrosive response data:
- The single application of 0.5 g silver(I) sulphate to the intact skin of three rabbits each caused only very slight changes.
A very slight erythema (grade 1) occurred in one animal only 48 hours after application and in another animal from 24 hours after application until day 4.
A very slight oedema (grade 1) was observed in one animal only 2 days after application, 24 hours later the finding had completely disappeared.
In addition, the treated skin areas of all three animals were brownish discoloured during the whole observation period.
The control sites did not show any reactions. - Other effects:
- Systemic toxic effects did not occur after dermal application of the test substance. The general conditions of the test animals was not affected.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Silver (I) sulphate is not irritating to the skin, according to EC-Regulation 1272/2008.
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