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EC number: 414-110-5 | CAS number: 1379678-96-2 ORASOL BLAU 761B
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on key study results, the test item is not irritating to the rabbit skin and causes serious damage to the rabbit eye (OECD 404 and 405, GLP). After 21 days, slight corneal opacity and pannus were still present.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In a primary skin irritation/corrosion study (RCC Notox BV, 1993), 3 young adult female New Zealand White rabbits were dermally exposed to 0.5 g of the moistened test item for a period of 4 hours. Animals then were observed for at least 72 hours after patch removal. Irritation was scored by the method of Draize (1959). In all animals, a mean score (24, 48 and 72 hours readings) of 0 for edema and 0.3 for erythema was noted. The very slight erythema (grade 1) observed in all animals at 24 hours resolved within 48 hours. In this study, the test item was no skin irritant.
In a primary eye irritation study (RCC Notox BV, 1993), approximately 55 mg of test item was placed in the conjunctival sac of each one eye of 3 young adult New Zealand White rabbits. The treated eyes were rinsed 24 hours after application. Animals were observed for 21 days following treatment. The scores of each animal (according to Draize, 1959) at the reading times 24, 48 and 72 hours after application were assessed for each type of lesion (corneal opacity, iris lesions, conjunctival redness and conjunctival chemosis). Under the conditions of this study, the treatment with the test item resulted in adverse effects on the cornea, iris and the conjunctivae in all animals. Corneal opacity (grade 1) and/or pannus was observed at termination in 2/3 animals. Also, the irritation of the conjunctivae had not completely resolved within the observation period of 21 days in any of the treated animals. Slight redness of the conjunctival tissues was still present in all animals at termination. Accordingly, under the conditions of this study, the test item was considered to cause serious damage to the rabbit eye.
Effects on eye irritation: highly irritating
Justification for classification or non-classification
The test item is not subject to classification for skin irritation according to Directive 67/548/EEC and Regulation 1272/2008/EC.
Due to the lack of full reversibility of cornea findings in 2/3 animals and conjunctival redness in 3/3 animals within the 21 -day observation period, the test item is subject to classification with Xi, R41 (risk of serious damage to eyes) according to Directive 67/548/EEC and Category 1, H318 (causes serious eye damage) according to Regulation 1272/2008/EC.
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