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Diss Factsheets
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EC number: 692-762-1 | CAS number: 166524-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in accordance with generally accepted scientific principles; however full data on methodology is not given and no information relating to GLP status is provided. Furthermore, sufficient information on substance identity is not provided. An accurate assessment of the study is therefore not considered to be possible.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): 2-ethoxy-4,6-difluoropyrimidine (DFEP) tar bottoms
- Appearance: dark brown, viscous liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.782 - 2.815 kg
No further information is provided on test animals and environmental conditions.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 7 days
- Number of animals:
- 2 (1 male and 1 female)
- Details on study design:
- TEST SITE
- Area of exposure: the backs of the rabbits were clipped with an electric clipper approximately 24 hours prior to test initiation.
- Test material administration: 0.5 mL of neat test material was applied to the test site and the animals bandaged for 4 hours o provide occlusion and prevent grooming of the application site.
SCORING
Four hours after application of the test material, the bandages were removed and the application sites were graded.
Results and discussion
In vivo
- Irritant / corrosive response data:
- One rabbit had slight erythema on the day of dosing. Both rabbits had slight erythema and oedema from test day 2 through to test day 4. On test day 7 both rabbits appeared normal.
- Other effects:
- There was no effect on the body weights of the rabbits (see Table 1).
Any other information on results incl. tables
Table 1: Individual Body Weights (kg)
Animal |
Test day |
|
1 |
7 |
|
1 |
2.782 |
2.866 |
2 |
2.815 |
2.914 |
Applicant's summary and conclusion
- Interpretation of results:
- other: It is not possible to assign a classification for skin irritation potential with the available data.
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the test material elicited only a slight response in both of the test animals. However, it is not possible to assign a classification for skin irritation potential with the available data.
- Executive summary:
The skin irritation potential of the test material was investigated in a study which was conducted to a methodology similar to that which is outlined in the standardised guideline OECD 404.
During the study, two New Zealand White rabbits were exposed to 0.5 mL of neat test material under an occluded wrap for four hours. Following the exposure period, the bandages were removed and the application sites were graded.
One rabbit had slight erythema on the day of dosing. Both rabbits had slight erythema and oedema from test day 2 through to test day 4. On test day 7 both rabbits appeared normal. There was no effect on the body weights of the rabbits.
Under the conditions of the study, the test material elicited only a slight response in both of the test animals. However, it is not possible to assign a classification for skin irritation potential with the available data.
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