Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 267-140-4 | CAS number: 67801-20-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Oral Toxicity: Key study >1000 mg/kg/day. Supporting study: >5000 mg/kg/day
Acute Dermal Toxicity: >2000 mg/kg/day.
Acute Inhalation Toxicity: Waiver based on relatively harmless levels of acute toxicity via the oral and dermal routes.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute – Oral
Key Study for Acute Oral In Vivo (Harlan Laboratories, 2010, OECD Guideline 423).
The oral administration of Ebanol to rats for a period of seven consecutive days at dose levels of 100, 500 and 1000 mg/kg/day produced no toxicologically effects in the parameters measured. The No Observed Adverse Effect Level (NOAEL) was therefore >1000 mg/kg/day.
The supporting study by Leberco Laboratories in 1984 (EPA OPP 81-1) showed that the LD50 of Ebanol in rats was >5000 mg/kg.
Based on the available acute toxicity studies and supporting data there is no need to classify Ebanol in accordance with 67/548/ and 1272/2008/EC.
Acute – Inhalation
The oral and dermal LD50 levels for Ebanol have been determined and both demonstrate relatively harmless levels of acute toxicity >2000 mg/kg bw and therefore do not require labelling under CLP.
Testing by the inhalation route in accordance with column 2 of AnnexVIIIof 1907/2006/EC, is therefore considered to be inappropriate as exposure of humans via inhalation is unlikely taking into account the vapour pressure of the substance (0.89 Pa at 25'C) and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size.
Acute – Dermal
Key Study for Acute Dermal In Vivo (Harlan Laboratories - 2010).
The acute dermal median lethal dose (LD50) of the test material in the Wistar strain rat was found to be greater than 2000 mg/kg bodyweight.
The acute dermal of Ebanol to rats at a dose level 2000 mg/kg/day produced no toxicologically effects in the parameters measured. The No Observed Adverse Effect Level (NOAEL) was therefore >2000 mg/kg/day.
Based on the available acute toxicity study data there is no need to classify Ebanol in accordance with 67/548/ and 1272/2008/EC.
Justification for classification or non-classification
Justification for classification or non classification
Based on the oral LD50 value >1000 (supporting data >5000mg/kg) and dermal LD50 values >2000 mg/kg bw, there is no need to classify Ebanol for acute toxicity in accordance with the criteria outlines in Annex VI of 67/548/EEC (DSD) and Annex I of 1272/2008/EC (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.