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Diss Factsheets
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EC number: 218-664-7 | CAS number: 2212-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD319b
- Deviations:
- yes
- Remarks:
- See below
- Principles of method if other than guideline:
- The aim of the OECD 319B is to determine the in vitro intrinsic clearance (CL in vitro int) of a test chemical using the substrate depletion approach. This can be applied to increase modelled predictions of bioaccumulation in fish. In short the clearance rate can be inputted into toxicokinetic models for fish bioaccumulation or extrapolated to a whole body biotransformation rate. See test guideline. The aim of this assay is to ultimately reduce animal testing in groups of similar substances, by more extensive use of such alternative tests. In addition the assay can be implemented in a simpler fashion to determine if a product is transformed and can be useful to aid degradation product identification. In this memo the
implementation of the assay for Trout and Rat liver is summarized and one test chemical was tested using the assay in order to establish if biotransformation occurred. No intrinsic clearance rate was calculated at this stage. - GLP compliance:
- no
Test material
- Reference substance name:
- [1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide
- EC Number:
- 246-678-3
- EC Name:
- [1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide
- Cas Number:
- 25155-25-3
- Molecular formula:
- C20H34O4
- IUPAC Name:
- Reaction mass of 1,3-bis[2-(tert-butylperoxy)propan-2-yl]benzene and 1,4-bis[2-(tert-butylperoxy)propan-2-yl]benzene
- Reference substance name:
- Di-tert-butyl α,α,α',α'-tetramethyl-(p-phenylenedimethylene) diperoxide
- EC Number:
- 220-479-1
- EC Name:
- Di-tert-butyl α,α,α',α'-tetramethyl-(p-phenylenedimethylene) diperoxide
- Cas Number:
- 2781-00-2
- Molecular formula:
- C20H34O4
- IUPAC Name:
- 1,4-bis[1-(tert-butylperoxy)-1-methylethyl]benzene
- Details on test material:
- - Name of test material (as cited in study report): [1,3(or 1,4)-Phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide
- Molecular formula (if other than submission substance): C20H34O4
- Molecular weight (if other than submission substance): 338.49
- Smiles notation (if other than submission substance): CC(c1ccc(cc1)C(OOC(C)(C)C)(C)C)(OOC(C)(C)C)C
- Substance type: Organic peroxide
Analytical purity: 97.6%
- Purity test date: 28 July 2009
- Lot/batch No.: 307090713
- Expiration date of the lot/batch: July 2010
- Storage condition of test material: Room temperature in the dark
- Other: Date received 22 September 2009
Constituent 1
Constituent 2
- Radiolabelling:
- no
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- No metabolic activity was observed for the test chemical.
- Executive summary:
The test chemical was used during the implementation of the OECD 319B assay. Performance of the assay was assessed using testosterone as a standard to demonstrate activity using both trout and rat liver S9 fractions. Multiple tests were conducted to establish an optimal concentration for use in subsequent tests as a positive control. After which, both rat and trout liver fractions gave an acceptable levels of testosterone metabolism and showed a sufficient level of reproducibility. Should definitive tests
take place an additional standard for phase II enzyme activity and day to day test variation still requires validation.
The test substance di(tert-butylperoxyisopropyl)benzene was tested with a rat liver S9 fraction at 50 and 200 μ/moles. No metabolic activity was observed for the test chemical. The meta isomer only was quantified. The reference material at 50 μ/moles performed normally demonstrating sufficient phase 1 activity in the cell line used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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