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EC number: 204-557-2 | CAS number: 122-60-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study which meets basic scientific principles.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Reference Type:
- publication
- Title:
- The inhalation toxicity of phenylglycidyl ether: reproduction, mutagenic, teratogenic, and cytogenetic studies
- Author:
- Terrill JB, Lee KP, Culik R, Kennedy GL
- Year:
- 1 982
- Bibliographic source:
- Toxicology and applied pharmacology 64, 204-212
- Reference Type:
- secondary source
- Title:
- Phenyl glycidyl ether
- Author:
- MAK Commission
- Year:
- 1 991
- Bibliographic source:
- MAK List 1991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Deviations:
- yes
- Remarks:
- limited documentation of results
Test material
- Reference substance name:
- propane, 1,2-epoxy-3-phenoxy
- IUPAC Name:
- propane, 1,2-epoxy-3-phenoxy
- Details on test material:
- - Name of test material (as cited in study report): propane, 1,2-epoxy-3-phenoxy
No further information.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Weight at study initiation: ca. 200 g
No further information.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Details on exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Chamber atmospheres were generated by syringe driving the liquid EPP into a heated (310°C) tube. The tube was housed in an oven and constructed in such a way that the nitrogen stream (10 liters/minute) which swept the vapors through the tube was the same temperature as the delivery tube. The exit port of the tube was connected to the top of a 4.5 m3 exposure chamber. Room air at 1,500 liters/minute was also drawn into the chamber at this point.
TEST ATMOSPHERE
- Brief description of analytical method used: Atmospheric samples were collected hourly in a midget impinger that contained 15 cc of 0:1 N NaOH in a 50:50 ethanol-water mixture. Analysis was by U.V. spectrophotometry at 270 nanometers.
- Samples taken from breathing zone: no data - Details on mating procedure:
- No further information.
- Duration of treatment / exposure:
- 6 hours/day between 4th and 15th day of gestation (day that mating was observed is designated day 1)
- Frequency of treatment:
- daily
- Duration of test:
- 16 days (animals were sacrificed on day 20)
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0, 1, 5, 12 ppm
Basis:
nominal conc.
corresponding to ca. 0, 0.006, 0.03, 0.07 mg/l (calculated by Derelanko M, 2008)
- Remarks:
- Doses / Concentrations:
0, 1.75, 5.84, 11.2 ppm
Basis:
analytical conc.
- No. of animals per sex per dose:
- 25
- Control animals:
- yes, sham-exposed
Examinations
- Maternal examinations:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: No data
BODY WEIGHT: Yes
- Time schedule for examinations: at start and end of the study
POST-MORTEM EXAMINATIONS:
- Sacrifice on gestation day 20
- Organs examined: no data - Ovaries and uterine content:
- The ovaries and uterine content was examined after termination: Yes
Examinations included:
- Gravid uterus weight: No
- Number of corpora lutea: Yes
- Number of implantations: Yes
- Number of early resorptions: Yes
- Number of late resorptions: Yes - Fetal examinations:
- - External examinations: Yes: [all per litter]
- Soft tissue examinations: Yes: [1/3 of the litters]
- Skeletal examinations: Yes: [2/3 of the litters]
- Head examinations: No data - Statistics:
- The number of implantations, live fetuses, and resorptions per litter were analyzed by the Mann-Whitney U test. Other parameters, such as partial resorptions, were analyzed by Fisher’s exact test.
- Indices:
- No data.
- Historical control data:
- No data.
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no data
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Effect levels (fetuses)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 0.07 mg/L air (nominal)
- Based on:
- test mat.
- Remarks:
- corresponding to 12 ppm
- Basis for effect level:
- other: teratogenicity
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 0.07 mg/L air (nominal)
- Based on:
- test mat.
- Remarks:
- corresponding to 12 ppm
- Basis for effect level:
- other: fetotoxicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Table 1: Effect of inhalation exposure to phenylglycidyl ether on the outcome of pregnancy and fetal development of the rat
|
Exposure levels (ppm) |
|||||||
|
0 (control) |
2 |
5 |
12 |
||||
Parameter |
Mean |
S.D. |
Mean |
S.D. |
Mean |
S.D. |
Mean |
S.D. |
Females bred |
25 |
|
25 |
|
25 |
|
25 |
|
Females pregnant (%) |
24 (96) |
|
24 (96) |
|
23 (92) |
|
21 (84) |
|
Corpora Lutea/pregnant female |
11.1 |
2.1 |
10.7 |
1.8 |
11.2 |
1.9 |
10.7 |
2.7 |
Implantations/litter |
9.5 |
1.7 |
9.3 |
2.2 |
9.8 |
1.0 |
9.2 |
1.9 |
Live fetuses/litter |
9.0 |
2.1 |
8.9 |
2.3 |
9.5 |
1.0 |
8.0 |
1.9 |
Litters with early resorptions (%) |
8 (33.3) |
|
7 (29.2) |
|
6 (26.1) |
|
6 (28.6) |
|
Litters with late resorptions (%) |
1 (4.2) |
|
0 |
|
0 |
|
0 |
|
Litters with partial resorptions (%) |
9 (37.5) |
|
7 (29.2) |
|
6 (26.1) |
|
6 (28.6) |
|
Resorptions/ litters with resorptions |
1.3 |
0.6 |
1.3 |
0.5 |
1.0 |
0.0 |
1.3 |
0.5 |
Initial body weight of pregnant female |
168.3 |
8.5 |
171.2 |
11.6 |
172.5 |
7.9 |
107.2 |
10.3 |
Final body weight of pregnant female |
289 |
17.9 |
283.8 |
22 |
290.7 |
21.4 |
279.4 |
20.7 |
Fetal crown-rump length (cm) |
3.8 |
0.2 |
3.7 |
0.1 |
3.7 |
0.2 |
3.7 |
0.2 |
Fetal weight (g) |
4.1 |
0.5 |
4.1 |
0.5 |
4.1 |
0.4 |
4.2 |
0.3 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.