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EC number: 230-039-0 | CAS number: 6921-34-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- other: Reliability score is not applicable because available data are on stabilizer agent (as described in sect. 1.2) and not on the benzylmagnesium chloride as such.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: According to the specification of the National Toxicology Program for the conduct of toxicity and carcinogenicity studies on chemicals
- GLP compliance:
- yes
- Remarks:
- Study is conducted in compliance with Food and Drug Administration Good Laboratory Practice Regulations.
Test material
- Reference substance name:
- Tetrahydrofuran
- EC Number:
- 203-726-8
- EC Name:
- Tetrahydrofuran
- Cas Number:
- 109-99-9
- Molecular formula:
- C4H8O
- IUPAC Name:
- tetrahydrofuran
- Test material form:
- other:
- Details on test material:
- Lot WK8-6-86 was used during the 14-week studies; it was identified as tetrahydrofuran by infrared, ultraviolet/visible, and nuclear magnetic resonance spectroscopy. All spectra were consistent with the literature spectra of tetrahydrofuran. Lot WK8-6-86 contained less than 1.5 ppm peroxide and the overall purity was determined to be approximately 99%.
The bulk chemical was stored at room temperature in the original metal containers under a nitrogen atmosphere to ensure stability. Stability was monitored during the 14-week study using gas chromatography. No degradation of the bulk chemical was detected.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air distribution line
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 5 days per week, for 14 weeks
- Frequency of treatment:
- 6 hours plus T90 (12 minutes) per day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 (chamber control), 66, 200, 600, 1800, 5000 ppm
Basis:
nominal conc.
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent no treatment
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 1 800 ppm
- Basis for effect level:
- other: level base on hemathology and clinical chemistry data of 5000 ppm group;
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Results of the 14 -week study
All rats survived until the end of the study. Final mean body weights and body weight gains of exposed groups of male and female rats were similar to those of the chamber controls. Immediately after exposure, male and female rats in the 5,000 ppm groups exhibited ataxia; animals had irregular movements with lack of coordination. Hematologic and biochemical data for rats demostrate minimal differences, with most values falling within physiologic ranges. The differences did not demonstrate an exposure relationship and only occurred in the 5000 ppm groups, but were not considered toxicologically relevant. In 5000 ppm rats, a minimal mature neutrophilia occurred, wich was evidenced by increased segmented neutrophil numbers. Microscopic evidence of a mild suppurative submucosal gastric inflammation could account for the neutrophilia. Minimal increase of of serum bile acid concentration occurred in 5000 ppm male and female rats and could be consistent with either cholestatic event or hepatocellular injury. There was no evidence of cholestasis or hepatocellular necrosis/leakage. Serum bile acid concentration can be affected by other mechanisms such as altered enterohepatic circulation and impaired hepatic function, and noncholestatic liver injury can increase circulating bile acid concentrations.
Absolute and relative thymus and spleen weights of male and female rats exposed to 5,000 ppm were significantly less than those of the chamber controls. Absolute and relative liver weights of female rats exposed to 5,000 ppm were significantly greater than those of the chamber controls. The decrease of spleen and thymus weights were not accompanied by readly appreciable histopathologic changes and may have been due to stress associated with tetrahydrofuran administration in these groups. No exposure-related gross lesions were observed in male or female rats at necropsy. Mimal suppurative inflammation characterized by submucosal neutrophilic infiltrates and edema was associated with areas of forestomach hyperplasia in two male and four female rats exposed to 5,000 ppm. The gastric lesions may have been due to the irritant effect of tetrahydrofuran ingested during exposure.
Applicant's summary and conclusion
- Conclusions:
- In this study, groups of 10 male and 10 female rats have been exposed to 0, 66, 200, 600, 1800, 5000 tetrahydrofuran inhalation for 14 weeks, 5 days per week. Immediately after exposure, rats in the 5000 ppm group exhibited ataxia, with irregular movements and lack of coordination. Hematology and clinical chemistry data differences between exposure groups did not demonstrate a strong exposure relationship and only occurred in the 5000 ppm group. However, these data were considered not toxicologically relevant. The decrease of thymus and spleen weights were not associated with readly appreciable histopathological changes and may have been due to stress associated with tetrahydrofuran administration. The gastric lesion observed may have been due to the irritant effect of tetrahydrofuran ingested during exposure. The only effect on liver of rats was the increase of absolute and relative weight of 5000 ppm.
- Executive summary:
In this study, groups of 10 male and 10 female rats have been exposed to 0, 66, 200, 600, 1800, 5000 tetrahydrofuran inhalation for 14 weeks, 5 days per week All rats survived until the end of the study. Final mean body weights and body weight gains of exposed groups of male and female rats were similar to those of the chamber controls. Immediately after exposure, male and female rats in the 5,000 ppm groups exhibited ataxia; animals had irregular movements with lack of coordination. Hematologic and biochemical data for rats demostrate minimal differences, with most values falling within physiologic ranges. The differences did not demonstrate an exposure relationship and only occurred in the 5000 ppm groups, but were not considered toxicologically relevant. In 5000 ppm rats, a minimal mature neutrophilia occurred, wich was evidenced by increased segmented neutrophil numbers. Microscopic evidence of a mild suppurative submucosal gastric inflammation could account for the neutrophilia.
Absolute and relative thymus and spleen weights of male and female rats exposed to 5,000 ppm were significantly less than those of the chamber controls. Absolute and relative liver weights of female rats exposed to 5,000 ppm were significantly greater than those of the chamber controls. The decrease of spleen and thymus weights were not accompanied by readly appreciable histopathologic changes and may have been due to stress associated with tetrahydrofuran administration in these groups. No exposure-related gross lesions were observed in male or female rats at necropsy. Mimal suppurative inflammation characterized by submucosal neutrophilic infiltrates and edema was associated with areas of forestomach hyperplasia in two male and four female rats exposed to 5,000 ppm. The gastric lesions may have been due to the irritant effect of tetrahydrofuran ingested during exposure.
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