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Diss Factsheets
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EC number: 208-235-2 | CAS number: 517-23-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- To determine the maintenance of test substance during the test period, the amount of dissolved organic carbon (DOG) was measured daily and compared with the initial concentration.
- Vehicle:
- no
- Details on test solutions:
- All dilutions were achieved using fresh urban tap water.
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Species
- Rainbow Trout (Salmo gairdneri)
- Length (average) : 5.8 cm
- Weight (average) : 2.6 g
- Source : P. Hohler, Zeiningen, Switzerland
- Date of delivery : 04.01 .l 991 - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Nominal and measured concentrations:
- Nominal concentration [mg/L]: 150, 250, 400, 600, 1000 + control
measured concentration after 96 h [mg/L]: 132, 226, 355, 549, 996 (after 24 h, no measuring afterwards) + control - Details on test conditions:
- All tests were performed in 30-litre glass aquaria. A steel spiral tube with running urban tap water held the temperature constant at 14 +- 1 °C. Oxygenation was achieved by constant aeration with compressed purified air by means of a glass aerator tube. The fish were exposed to five concentrations: 150, 250, 400, 600, 1000 + control. Ten fish were used per concentration of the test substance. Food was withheld from the trouts two days before and throughout the test. The test duration was 96 h.
- Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 730 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- An 96h-EC50 of 730 mg/L was determined for the test item towards fish.
- Executive summary:
In this study the acute toxicity of the test substance towards fish was estimated by continuous exposure of rainbow trouts for 96 hours, according to OECD guideline 203. Following an acclimation and adaptation period, groups of ten trouts were exposed under controlled conditions, using a static test system, to five different concentrations of the test compound (150, 250, 400, 600, 1000 mg/L). As a control, a group of ten fish was exposed to normal urban tap water. Fish were observed daily and behavior and mortality were recorded. An 96h-EC50 of 730 mg/L was determined for the test item towards fish.
Reference
Description of key information
In this study the acute toxicity of the test substance towards fish was estimated by continuous exposure of rainbow trouts for 96 hours, according to OECD guideline 203. Following an acclimation and adaptation period, groups of ten trouts were exposed under controlled conditions, using a static test system, to five different concentrations of the test compound (150, 250, 400, 600, 1000 mg/L). As a control, a group of ten fish was exposed to normal urban tap water. Fish were observed daily and behavior and mortality were recorded. An 96h-EC50 of 730 mg/L was determined for the test item towards fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 730 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.