Registration Dossier
Registration Dossier
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EC number: 206-420-2 | CAS number: 338-83-0
Endpoint summary
Administrative data
Description of key information
An eye irritation study was conducted on perfluorotripropylamine. No signs of eye irritation were observed at 1, 24, 48 and 72 hours.
A Primary Skin Irritation Study was conducted. The animals showed no signs of irritation at 24, 48 and 72 hours.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The ocular irritation/corrosion potential of T-5912 was assessed in New Zealand White rabbits. The undiluted test article (0.1 mL) was placed into the everted lower lid of the right eye, with the left eye serving as the untreated control. The upper and lower lids were held together for 1 second and then released. The eyes remained unflushed. The treated eyes were observed for ocular irritation at 1, 24, 48 and 72 hours after treatment. Irritation was scored using the Draize technique. A sodium fluorescein examination was used to reveal possible corneal damage at 72 hours. Average primary irritation scores and individual eye irritation scores for cornea, iris, conjunctivae irritation were reported. All animals and all time points had irritation scores of zero.
Test article was applied to intact skin of six albino rats and then covered with a semi-occlusive dressing. The dressing was removed after 24 hours. There were no signs of irritation 30 minutes after the dressing was removed. The sites were evaluated at 24, 48 and 72 hours. There were no signs of irritation at any time.
Justification for classification or non-classification
The criteria for classification were not met.
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