Registration Dossier
Registration Dossier
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EC number: 237-380-4 | CAS number: 13768-11-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Non GLP study; no lysis time; no data on positive/negative controls
Data source
Reference
- Reference Type:
- other: study summary
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Toxicity to chorioallantoic membrane of a chicken egg
- GLP compliance:
- no
Test material
- Reference substance name:
- Dirhenium heptaoxide
- EC Number:
- 215-241-9
- EC Name:
- Dirhenium heptaoxide
- Cas Number:
- 1314-68-7
- IUPAC Name:
- 1314-68-7
- Reference substance name:
- Rhenium (VII) oxide
- IUPAC Name:
- Rhenium (VII) oxide
- Details on test material:
- - Name of test material (as cited in study report): Rhenium (VII) oxide
- Physical state: no data
- Analytical purity: no data
- Lot/batch No.: 0095/01-2C07-BS
Constituent 1
Constituent 2
Test system
- Vehicle:
- water
- Amount / concentration applied:
- undiluted substance and a 10% solution in doubly- distilled water
- Duration of treatment / exposure:
- not applicable
- Observation period (in vivo):
- up to 65 seconds
- Details on study design:
- Undiluted substance applied to one egg and 10% solution applied to 3 eggs. Time (seconds) to appearance of haemorrhagia and coagulation assessed.
Results and discussion
In vivo
- Irritant / corrosive response data:
- Undiluted substance - haemorrhagia and coagulation after 1 sec
10% solution - haemorrhagia - 22.7 sec (mean) ; coagulation - 58.7 sec (mean)
Applicant's summary and conclusion
- Interpretation of results:
- other: May cause severe eye damage
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- The test substance may cause severe eye damage.
- Executive summary:
The effect of the test substance, rhenium (VII) oxide on chick chorioallantoic membrane in vitro (using the HET-CAM assay) has been examined to assess potential ocular corrosivity/severe irritancy.
Application of the undiluted test substance caused rapid haemorrhage and coagulation (in 1 sec), whereas application of a 10% solution in doubly-distilled water resulted in haemorrhage in between 15 and 35 sec (mean 22.7 sec) and protein coagulation in between 54 and 65 sec (mean 58.7 sec). Because of the absence of vascular lysis data, and irritation score (IS) can not be determined.
This study suggests that rhenium (VII) oxide may cause severe eye damage.
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