2,2-dimethyloxirane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1979-1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

Principles of method if other than guideline:

BASF-Test, see details in the section "Any other information on materials and methods incl. tables".

GLP compliance:

no

Remarks:

study was performed prior to GLP implementation

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,2-dimethyloxirane

EC Number:

209-193-8

EC Name:

2,2-dimethyloxirane

Cas Number:

558-30-5

Molecular formula:

C4H8O

IUPAC Name:

2,2-dimethyloxirane

Details on test material:

Please refer to the section "confidential details on test material" below.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: young adult (based on body weight)
- Weight at study initiation: 200 to 210 g (male), 180 - 200 g (female)
- Fasting period before study: 15 - 20 h before application
- Diet: H. EGGERSMANN KG, Germany

IN-LIFE DATES: From: 1979-07-17 To: 1979-07-31

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Remarks:

(0.5 % aqueous solution)

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 14.7, 21.5, 31.6, 46.4 and 50.0 % emulsion in aqueous 0.5 % carboxymethyl cellulose

Doses:

1470, 2150, 3160, 4640, 6810 mg/kg bw

No. of animals per sex per dose:

5 animals

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of application and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, macroscopical examination

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

3 890 mg/kg bw

Based on:

test mat.

95% CL:

>= 2 799 - <= 5 466

Mortality:

See details in the section "Any other information on results incl. tables".

Clinical signs:

other: Clinical signs were observed after a single dosage of 3160, 4640 and 6810 mg/kg bw: - dyspnoe - apathy - aberrant position - tumbling - ruffy fur - diarrhoea - exsiccosis - salivation - reduced general state

Gross pathology:

Animals died during the study: heart - right-sided acute dilatation, acute hyperaemia
Animals sacrificed: gluing of the rumen wall to the peritoneum

Any other information on results incl. tables

Mortality:

Dose (mg/kg bw)	Gender	1 h	24 h	48 h	7 days	14 days
6810	male	0/5	2/5	2/5	2/5	2/5
6810	female	0/5	5/5	5/5	5/5	5/5
4640	male	2/5	2/5	2/5	2/5	2/5
4640	female	0/5	5/5	5/5	5/5	5/5
3160	male	0/5	2/5	2/5	2/5	2/5
3160	female	0/5	3/5	4/5	4/5	4/5
2150	male	0/5	0/5	0/5	0/5	0/5
2150	female	0/5	0/5	0/5	0/5	0/5
1470	male	0/5	0/5	0/5	0/5	0/5
1470	female	0/5	0/5	0/5	0/5	0/5

The test substance caused dose dependent toxicity after a single ingestion.