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Diss Factsheets
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EC number: 203-593-6 | CAS number: 108-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Glutaric anhydride
- EC Number:
- 203-593-6
- EC Name:
- Glutaric anhydride
- Cas Number:
- 108-55-4
- Molecular formula:
- C5H6O3
- IUPAC Name:
- glutaric anhydride
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- Females
2g, 4g, 8g /kg bw
Males
2g, 4g, 5.66g, 8g /kg bw - No. of animals per sex per dose:
- Males: 5 per dose for the 4, 5.66 and 8 g/kg bw doses, 2 per dose for the 2 g/kg bw dose
Females: 5 per dose for all doses - Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 250 mg/kg bw
- 95% CL:
- > 5 340 - < 7 330
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5 660 mg/kg bw
- 95% CL:
- 3 210 - 9 950
Any other information on results incl. tables
By the percutaneous route, the LD50 for male rabbits was 6.25 g/kg. The LD50 for females was 5.66 g/kg. Local dermal effects included erythema, edema, necrosis, ecchymosis, desquamation, fissuring, ulceration, scabs and alopecia. Sluggishness, unsteady gait and emaciation were among the signs of toxicity observed. Time to death usually ranged from one to 3 days. One female succumbed at 10 days. One affected survivor recovered at 2 days. Gross pathologic findings included salmon-colored to red lungs, lungs of one with tan nodules and adhesions, one dark-red liver with tan areas, one distended abdomen, stomachs with multiple black foci (in 2), one light-red thymus, pale-tan kidneys or pitted kidneys and subcutaneous edema in one.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Whilst the substance appears to be severely irritating under the circumstances of the study, it did not demonstrate significant systemic toxicity and both LD50 values for male and female rabbits were in excess of 5000 mg/kg bw. Therefore the test substance does not meet the critera for classification for acute dermal toxicity.
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