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Diss Factsheets
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EC number: 233-238-0 | CAS number: 10099-59-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Well documented, scientifically sound study with methods similar to OECD 401 with the following deviations: The number of deaths at each dose were not reported; the specific doses (mg/kg) were not provided; individual clinical observations, body weights, pathology were not reported; sex of the animals was not provided
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute toxicity of zirconium, columbium, strontium, lanthanum, cesium, tantalum, and yttrium
- Author:
- Cochran KW, Doull J, Mazur M, DuBois KP.
- Year:
- 1 950
- Bibliographic source:
- Industrial Hygiene and Occupational Medicine 1: 637-650,
- Reference Type:
- secondary source
- Title:
- Sax's Dangerous Properties of Industrial Materials
- Author:
- Lewis
- Year:
- 1 995
- Bibliographic source:
- 9th ed, Van Nostrand Reinhold, New York, page 2021, ref. AIHOAX 1,637,50
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- The number of deaths at each dose were not reported; the specific doses (mg/kg) were not provided; individual clinical observations, body weights, pathology were not reported; sex of the animals was not provided
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Lanthanum trinitrate
- EC Number:
- 233-238-0
- EC Name:
- Lanthanum trinitrate
- Cas Number:
- 10099-59-9
- Molecular formula:
- H3LaN3O9+3
- IUPAC Name:
- lanthanum trinitrate
- Details on test material:
- - Name of test material (as cited in study report): Lanthanum nitrate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: adult
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
Animals were maintained in air conditioned rooms.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50% solution - Doses:
- The solution was given in single doses by stomach tube. No further information on doses provided.
- No. of animals per sex per dose:
- 24 rats in total
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: All animals were observed for 10 days. An initial group of animals receiving the test substance were kept for 30 days to verify if any significant mortality occurred after the tenth day.
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data - Statistics:
- The LD50 values were obtained from ten day mortality data by using the log-probability method.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: i.e. 1450 mg La/kg bw
- Mortality:
- No further details reported. No sex differences were noted.
- Clinical signs:
- other: No further details reported.
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 was calculated to be 4500 mg compound/kg bw.
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